ID A0A452RZ20_URSAM Unreviewed; 435 AA.
AC A0A452RZ20;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Threonine synthase-like 2 {ECO:0000256|ARBA:ARBA00021942};
GN Name=THNSL2 {ECO:0000313|Ensembl:ENSUAMP00000024792.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000024792.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000024792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR AlphaFoldDB; A0A452RZ20; -.
DR STRING; 9643.ENSUAMP00000024792; -.
DR Ensembl; ENSUAMT00000027677.1; ENSUAMP00000024792.1; ENSUAMG00000019338.1.
DR GeneTree; ENSGT00940000158503; -.
DR OMA; FDDCQDM; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR42690; THREONINE SYNTHASE FAMILY MEMBER; 1.
DR PANTHER; PTHR42690:SF1; THREONINE SYNTHASE-LIKE 2; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 3..81
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT DOMAIN 105..400
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT REGION 408..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 113
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 435 AA; 48386 MW; 3D2CE3D8A3A49A9A CRC64;
MWYVSTRGMA PRVDFEGALF SGYAPDGGLF MPEELPQLHI QTLRQWSALS YPSLVKELCT
LFIGPELIPR DVLNDLIDRA FRRFRCREVV HLSRLRDGLN VLELWHGATY AFKDLSLCCT
AQFLQYFLEK KEKHVTVVVG TSGDTGSAAI ESVQGAKNVD IIVLLPQGHC TKIQELQMTT
VLSENVHVFG VEGNSDELDE PIKAVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF
QCASSLDTHP LPPVEVVVPT GAAGNLAAGC IAQKMGLPIR LVVAVNRNDI IHRTVQRGDF
SLSEAVEPTL ASAMDIQVPY NMERIFWLLS GSDSQGTRAL MEQFERTQST SLPKELHSKL
LGAVTSESVS DEAITRTMGR CWEENRYLLC PHSAVAVSYH YRQTDRQQPR YGRWTPGSPG
TLAFGGPPPP QAGEI
//
