ID A0A452RZ59_URSAM Unreviewed; 424 AA.
AC A0A452RZ59;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Origin recognition complex subunit 5 {ECO:0000313|Ensembl:ENSUAMP00000024888.1};
GN Name=ORC5 {ECO:0000313|Ensembl:ENSUAMP00000024888.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000024888.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000024888.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC5 family.
CC {ECO:0000256|ARBA:ARBA00006269}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452RZ59; -.
DR STRING; 9643.ENSUAMP00000024888; -.
DR Ensembl; ENSUAMT00000027785.1; ENSUAMP00000024888.1; ENSUAMG00000019414.1.
DR GeneTree; ENSGT00390000009380; -.
DR OMA; QLRRWHG; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR020796; ORC5.
DR InterPro; IPR047088; ORC5_C.
DR InterPro; IPR048866; ORC5_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12705; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12705:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 5; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14630; ORC5_C; 1.
DR Pfam; PF21639; ORC5_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 8..154
FT /note="Orc1-like AAA ATPase"
FT /evidence="ECO:0000259|Pfam:PF13191"
FT DOMAIN 204..271
FT /note="ORC5 lid"
FT /evidence="ECO:0000259|Pfam:PF21639"
FT DOMAIN 302..420
FT /note="Origin recognition complex subunit 5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14630"
SQ SEQUENCE 424 AA; 48889 MW; 6CD5A160155DB282 CRC64;
MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF
MNCVECFTSR LLLEQILNKL NHLRSSEGGC STHITCETFN DFVRLFKQIT KAESLKDQTV
YIVLDKAEYL RDMEANLLPG FLRLQELTDR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP
DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV
VKGEANERDT RKLWRNIEPH LKRAMQTVYL REISSSQWEK VQKDDTDPAQ LKGLSAYTHV
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTSF LKKHEKTSNH LLGPKPFPLD
RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA
SISP
//
