ID A0A452RZF1_URSAM Unreviewed; 388 AA.
AC A0A452RZF1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=ethanolamine kinase {ECO:0000256|ARBA:ARBA00038874};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
GN Name=CHKA {ECO:0000313|Ensembl:ENSUAMP00000024899.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000024899.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000024899.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR AlphaFoldDB; A0A452RZF1; -.
DR STRING; 9643.ENSUAMP00000024899; -.
DR Ensembl; ENSUAMT00000027796.1; ENSUAMP00000024899.1; ENSUAMG00000019419.1.
DR GeneTree; ENSGT00950000182939; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0004103; F:choline kinase activity; IEA:Ensembl.
DR GO; GO:0004104; F:cholinesterase activity; IEA:Ensembl.
DR GO; GO:0004305; F:ethanolamine kinase activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:Ensembl.
DR CDD; cd05156; ChoK_euk; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603:SF36; CHOLINE KINASE ALPHA; 1.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 388 AA; 45003 MW; 6CBFCBE7DE7ABC1D CRC64;
RTQLGGPAAT APLPPPPPLP LPPPPPPADE QPEPRTRRRA YLWCKEFLPG AWRGLREDQF
HISVIRGGLS NMLFQCSLPD TVATIGDEPR KVLLRLYGAI LKMGAEAMVL ESVMFAILAE
RSLGPKLYGI FPQGRLEQFI PSRRLDTEEL SLPDISAEIA EKMATFHGMK MPFNKEPKWL
FGTMEKYLNQ VLRIKFAGEP RVKQLHRLLR LNLPLELECL RSLLESTPSP VVFCHNDCQE
GNILMLEGRE NSEKQRLMLI DFEYSSYNYR GFDIGNHFCE WMYDYNYEKY PFFRANTLKY
PTKRQQLHFI SNYLAAFHNE FENLSNEEKS IIEEDMLLEV NRFALASHFF WGLWSIVQAK
ISSIEFGYMD YAQARFDAYF DQKRKLGV
//
