ID A0A452S1E8_URSAM Unreviewed; 583 AA.
AC A0A452S1E8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Leiomodin 1 {ECO:0000313|Ensembl:ENSUAMP00000025876.1};
GN Name=LMOD1 {ECO:0000313|Ensembl:ENSUAMP00000025876.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000025876.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000025876.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
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DR AlphaFoldDB; A0A452S1E8; -.
DR STRING; 9643.ENSUAMP00000025876; -.
DR Ensembl; ENSUAMT00000028871.1; ENSUAMP00000025876.1; ENSUAMG00000020098.1.
DR GeneTree; ENSGT00940000159825; -.
DR OMA; NQTEKQP; -.
DR OrthoDB; 2883785at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005523; F:tropomyosin binding; IEA:InterPro.
DR GO; GO:0045010; P:actin nucleation; IEA:Ensembl.
DR GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR004934; TMOD.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR10901:SF5; LEIOMODIN-1; 1.
DR PANTHER; PTHR10901; TROPOMODULIN; 1.
DR Pfam; PF03250; Tropomodulin; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 557..576
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 28..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..528
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 64629 MW; C5F06D35537EDC8B CRC64;
MSKVAKYRRQ VSEDPDIDSL LSTLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKPPL
GTYNREAMLN FCEKETKKLI QREMSMDESK QVETKTDAKN GEERGRDASK KPLGPRRDSD
LGKEPKRGGL KKSFSRDKDE ADGKSGEKPK EEKLIRGIDK GRVRAAVDKK EAGKEGKGEE
KTAAPRKEDE KKGSDRSAGP SRDKDKKREE KETSKREDDG KGKGESRSAD AKKEDERMKR
GSGKTDTKRE EEKVKTDEAV SEKEPKEESK TQAQEKPAAA CPTKPSEGPA KAEEEAAPSI
FDEPLERVKN NDPEMTEVNV NNSDCITNEI LVRFTEALEF NTVVKVFALA NTRADDHVAF
AIAIMLKANK TITSLNLDSN HITGKGILAI FRALLQNNTL TELRFHNQRH ICGGKTEMEI
AKLLKENTTL LKLGYHFELA GPRMTVTNLL SRNMDKQRQK RLQEQRQAQE AGGDKKDLLE
VPKPGALAKG SPKASPQPSP KASPKNSPKK GGAPAAPPPP PPPLAPPLIM ENLKNSLSPA
TQRKMGDKVL PVQEKNSRDQ LLAAIRSSNL KQLKKVEVPK LLQ
//
