ID A0A452S2H0_URSAM Unreviewed; 245 AA.
AC A0A452S2H0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Complement C1q C chain {ECO:0000313|Ensembl:ENSUAMP00000026271.1};
GN Name=C1QC {ECO:0000313|Ensembl:ENSUAMP00000026271.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000026271.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000026271.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9643.ENSUAMP00000026270; -.
DR Ensembl; ENSUAMT00000029308.1; ENSUAMP00000026270.1; ENSUAMG00000020369.1.
DR Ensembl; ENSUAMT00000029309.1; ENSUAMP00000026271.1; ENSUAMG00000020369.1.
DR GeneTree; ENSGT00940000161227; -.
DR OMA; RGTNEYP; -.
DR OrthoDB; 3683851at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0062167; C:complement component C1q complex; IEA:Ensembl.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:Ensembl.
DR GO; GO:0030853; P:negative regulation of granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0045650; P:negative regulation of macrophage differentiation; IEA:Ensembl.
DR GO; GO:0098883; P:synapse pruning; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427:SF29; COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C; 1.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..245
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040596614"
FT DOMAIN 115..245
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 44..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 25671 MW; 293B3D7CDFE4415A CRC64;
MVMGSSSRPH LGLDLLLLLL ALPLGGQAST GCYGIPGMPG LPGAPGKDGY DGLPGPKGEP
GIPAIPGTRG PKGQKGEPGT PGFPGKNGPM GTPGIPGLPG LKGPPGEPGE EGRYKQKHQS
VFTVTRQTAE YPRPNSLVKF NTVITNPQGD YDTSTGKFTC KVPGLYYFVY HASQTANLCV
HLYRSGNKVT TFCDHMSNSK QVSSGGVLLR LQVGEQVWLA VNDYHGMVGT EGSDSVFSGF
LLFPD
//
