ID   A0A452S2J9_URSAM        Unreviewed;       846 AA.
AC   A0A452S2J9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Potassium channel tetramerization domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000026178.1};
GN   Name=KCTD1 {ECO:0000313|Ensembl:ENSUAMP00000026178.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000026178.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000026178.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR   AlphaFoldDB; A0A452S2J9; -.
DR   STRING; 9643.ENSUAMP00000026178; -.
DR   Ensembl; ENSUAMT00000029207.1; ENSUAMP00000026178.1; ENSUAMG00000020308.1.
DR   GeneTree; ENSGT00940000156453; -.
DR   OMA; DWEEPLE; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18387; BTB_POZ_KCTD1; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR048599; BTB_POZ_KCTD1.
DR   InterPro; IPR021893; DUF3504.
DR   InterPro; IPR048595; KCTD1-15-like_C.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR21446:SF3; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD1 ISOFORM X1; 1.
DR   PANTHER; PTHR21446; DUF3504 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF12012; DUF3504; 1.
DR   Pfam; PF20871; KCTD1-15_CTD; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          619..721
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|SMART:SM00225"
FT   REGION          1..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          560..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..113
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  94055 MW;  BDA0C33AA7D91A34 CRC64;
     MARMPGSGDC NTSAGGSASA AAAAAENNGE RGEGERGAGG RGRRHGRPHY CSAGEEEEEE
     EEDDEIQEVQ ITGDEEEEDG GGGLEEDEEE EEEEEEMGLD WDEPLEPEDS AGEELEPEPV
     HMINMDQSAA LEPEAPPRLL APRARGGPPG DSAELDPDVL QRPERARLSE NTRLATRYAV
     RIFREYLSEK AQSPDFETMD KGALCRVLRS FYAEARSKSG QLYSKSSLIS IRSSLNRYLN
     EPPYCRTLDL TKDPELRSAN LTLAAVIRKL EEQGAGPVVQ KQAITRADLR KLYTSSVFST
     NTPFGLLNKV WFETCMYFCT RGRENQRELE EDSFGLAMDE DGRKFVYFKS LGPYHKSRSS
     SWSKKRAESS DEENLPRMYE TGTEFCPYAS FVKYLSKRNP LCKAFFQRPR DHCSEGDVTW
     YENKAIGKNL LGTRMQMLSK AAKLSKTYTN HCIGAVSIAT LNSIAGIGTK LGSPAPQGCY
     ADALNGAPPS LGNTYILPKD SQVGPDVKSE AAPKRALYES VFGSGDICGP SSPKRLCIRP
     SEPVDAVVVV SVKHDPLPLL PEANGHRSTN SPTVVSPAIV SPTQDSRPNM SRPLITRSPA
     SPLNNQGIPT PAQLTKSNAP VHIDVGGHMY TSSLATLTKY PESRIGRLFD GTEPIVLDSL
     KQHYFIDRDG QMFRYILNFL RTSKLLIPDD FKDYTLLYEE AKYFQLQPML LEMERWKQDR
     ETGRFSRPCE CLVVRVAPDL GERITLSGDK SLIEEVFPEI GDVMCNSVNA GWNHDSTHVI
     RFPLNGYCHL NSVQVLERLQ QRGFEIVGSC GGGVDSSQFS EYVLRRELRR TPRVPSVIRI
     KQEPLD
//