ID A0A452S3I3_URSAM Unreviewed; 546 AA.
AC A0A452S3I3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=CAP-Gly domain containing linker protein 3 {ECO:0000313|Ensembl:ENSUAMP00000026590.1};
GN Name=CLIP3 {ECO:0000313|Ensembl:ENSUAMP00000026590.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000026590.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000026590.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452S3I3; -.
DR STRING; 9643.ENSUAMP00000026590; -.
DR Ensembl; ENSUAMT00000029657.1; ENSUAMP00000026590.1; ENSUAMG00000020578.1.
DR GeneTree; ENSGT00940000159557; -.
DR OMA; KAESAMI; -.
DR OrthoDB; 2914056at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:Ensembl.
DR GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0035594; F:ganglioside binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0044091; P:membrane biogenesis; IEA:Ensembl.
DR GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:0010828; P:positive regulation of glucose transmembrane transport; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0098840; P:protein transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR PANTHER; PTHR18916:SF77; CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 3; 1.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01302; CAP_GLY; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01052; CAP_GLY; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 2.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00845; CAP_GLY_1; 2.
DR PROSITE; PS50245; CAP_GLY_2; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT REPEAT 196..228
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 313..355
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT DOMAIN 435..477
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 59549 MW; 49F82015CD95E808 CRC64;
MTKTDPAPMA PPLRGEEEEE EEDELVPEAP SPTQERRQKP VVHPSAPAPL PKDYAFTFFD
PNDPACQEIL FDPQTTIPEL FAIVRQWVPQ VQHKIDVIGN EILRRGCHVN DRDGLTDMTL
LHYACKAGAH GVGDPAAAVR LSQQLLALGA DVTLRSRWTN MNALHYAAYF DVPDLVRVLL
KGARPRVVNS TCSDFNHGSA LHIAASNLCL GAAKCLLEHG ANPALRNRKG QVPAEVVPDP
MDMSLDKAEA ALVAKELRTL LEEAVPLSCA LPKVTLPNYD NVPGNLMLSA LGLRLGDRVL
LDGQKTGTLR FCGTTEFASG QWVGVELDEP EGKNDGSVGG VRYFICPPKQ GLFASVSKIS
KVVDAPPSSV TSTPRTPRMD FSRVTGKGRR EHKGKKKPPS SPSLGSLQQR EGAKAEVGDQ
VLVAGQKQGI VRFFGKTDFA PGYWYGIELD QPTGKHDGSV FGVRYFTCPP RHGVFAPASR
IQRIGGSTDP PGDNVGAKKV HQVTMTQPKR TFTTVRTPKD IASENSISRL LFCCWFPWML
RAEMQS
//
