ID A0A452S4D2_URSAM Unreviewed; 1195 AA.
AC A0A452S4D2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=PTPRF interacting protein alpha 1 {ECO:0000313|Ensembl:ENSUAMP00000026904.1};
GN Name=PPFIA1 {ECO:0000313|Ensembl:ENSUAMP00000026904.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000026904.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000026904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR AlphaFoldDB; A0A452S4D2; -.
DR Ensembl; ENSUAMT00000029999.1; ENSUAMP00000026904.1; ENSUAMG00000019465.1.
DR GeneTree; ENSGT01050000244900; -.
DR OMA; DHTFDAQ; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 883..949
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 975..1019
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1044..1113
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 219..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..126
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 464..512
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 219..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 134689 MW; DFBEFA17B5DC35CE CRC64;
PQAALETLCS RVRGPPGRVR CRAHRVLGGQ DVVQCQKSIK RQSLIVRVLP KLRDKASLEL
IQRKGSEPRR LKTPVSLRFC CPQEFAALTK ELNVCREQLL EREEEIAELK AERNNTRLLL
EHLECLVSRH ERSLRMTVVK RQAQSPAGVS SEVEVLKALK SLFEHHKALD EKVRERLRVA
LERCSLLEEE LGATHKELMI LKEQNNQKKT LTDGVLDMNH EQENTPSTNG KRSSDGSLSH
EEDLAKVIEL QDIIDKQSKE QSQMKERLAA LSSHVAELEE DLDTARKDLI KSEEVNTKLQ
RDVREAMAQK EDMEERITTL EKRYLAAQRE ATSVHDLNDK LENEIANKDS MHRQTEDKNR
QLQERLELAE QKLQQTLRKA ETLPEVEAEL AQRVAALSKA EERHGNIEER LRQMEAQLEE
KNQELQRARQ REKMNEEHNK RLSDTVDKLL SESNERLQLH LKERMAALED KNSLLREVET
AKKQLEEAQH DKDQLVLNVE ALRAELDQTR LRGMPLHHGR PHLGSVPDFR FPVADGPTDS
YSSSAVLRRP QKGRLAALRD EPSKVQTLNE QDWERAQQAS VLANVAQAFE SDVDVSDGED
DRDTLFSSAA LLSPSGQADA QTLAMMLQEQ LDAINKEIRL IQEEKESTEQ RAEEIESRVG
SGSLDSPGRF RSVGAAPQHP TSTLTGPSPP HSGRSTPRRG PHSPAREVDR LGVMTLPSDL
RKHRRKLPAS REEVRDDKAT IKCETSPPSS PRSLRLDRLH KGALHTVSHE DIRDVRNSTG
SQDGPVSNPS SSNSSQDSLH KAPKKKGIKS SIGRLFGKKE KGRPGHAGKE PTGPAATSET
ENSSQDALGL SKLGGQAEKN RKLQKKHELL EEARRQGLPF AQWDGPTVVV WLELWVGMPA
WYVAACRANV KSGAIMSALS DTEIQREIGI SNPLHRLKLR LAIQEIMSLT SPSAPPTSRT
TLAYGDMNHE WIGNEWLPSL GLAQYRSYFM ECLVDARMLD HLTKKDLRGQ LKMVDSFHRC
FCKCCFSSLV FTKTEIKAKN VLVWSNDRVI RWILSIGLKE YANNLVESGV HGALIALDET
FDANALALLL QIPTQNTQAR AVLEREFNNL LVMGTDRRFD EDDDKSFRRA PSWRKKFRPK
DVRGLAAGSA ETLPANFRVT SSLSSPSMQP KKMQLDGSVS GPQRLDSATV RTYSC
//
