ID   A0A452S4S2_URSAM        Unreviewed;       260 AA.
AC   A0A452S4S2;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Troponin T, fast skeletal muscle {ECO:0000256|ARBA:ARBA00014961};
GN   Name=TNNT3 {ECO:0000313|Ensembl:ENSUAMP00000027052.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027052.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000027052.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC       the thin filament regulatory complex which confers calcium-sensitivity
CC       to striated muscle actomyosin ATPase activity.
CC       {ECO:0000256|ARBA:ARBA00003363}.
CC   -!- SIMILARITY: Belongs to the troponin T family.
CC       {ECO:0000256|ARBA:ARBA00008330}.
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DR   AlphaFoldDB; A0A452S4S2; -.
DR   STRING; 9643.ENSUAMP00000027052; -.
DR   Ensembl; ENSUAMT00000030164.1; ENSUAMP00000027052.1; ENSUAMG00000020868.1.
DR   GeneTree; ENSGT00940000158477; -.
DR   OMA; EEXLTAP; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005861; C:troponin complex; IEA:Ensembl.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0005523; F:tropomyosin binding; IEA:Ensembl.
DR   GO; GO:0030172; F:troponin C binding; IEA:Ensembl.
DR   GO; GO:0031013; F:troponin I binding; IEA:Ensembl.
DR   GO; GO:0006942; P:regulation of striated muscle contraction; IEA:Ensembl.
DR   GO; GO:0003009; P:skeletal muscle contraction; IEA:Ensembl.
DR   Gene3D; 1.20.5.350; -; 1.
DR   InterPro; IPR027707; TNNT.
DR   InterPro; IPR001978; Troponin.
DR   InterPro; IPR038077; Troponin_sf.
DR   PANTHER; PTHR11521; TROPONIN T; 1.
DR   PANTHER; PTHR11521:SF4; TROPONIN T, FAST SKELETAL MUSCLE; 1.
DR   Pfam; PF00992; Troponin; 1.
DR   SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE   3: Inferred from homology;
KW   Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   REGION          111..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..150
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  30068 MW;  B62CB4FE44830196 CRC64;
     MVDYTSDQSK GQAVCPQLGA WARGQEGQSP GRVSTCPCSR ASLFFRLTAP KIPEGEKVDF
     DDIQKKRQNK DLMELQALID SHFEARKKEE EELIALKERI EKRRAERAEQ QRIRAEKERE
     RQNRLAEEKA RREEEDAKRR AEDDLKKKKA LSSMGANYSS YLAKADQKRG KKQTAREMKK
     KVLAERRKPL NIDHLGEDKL RDKAKELWET LYQLEIDKFE FGEKLKRQKY DVTAEDQLAS
     ICSSKKAGAP AKGKVGGRWK
//