ID A0A452S5G9_URSAM Unreviewed; 1455 AA.
AC A0A452S5G9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=DNA topoisomerase II binding protein 1 {ECO:0000313|Ensembl:ENSUAMP00000027321.1};
GN Name=TOPBP1 {ECO:0000313|Ensembl:ENSUAMP00000027321.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027321.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSUAMT00000030541.1; ENSUAMP00000027321.1; ENSUAMG00000020744.1.
DR GeneTree; ENSGT00940000157001; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd17737; BRCT_TopBP1_rpt1; 1.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR CDD; cd17718; BRCT_TopBP1_rpt3; 1.
DR CDD; cd17749; BRCT_TopBP1_rpt4; 1.
DR CDD; cd18434; BRCT_TopBP1_rpt5; 1.
DR CDD; cd17727; BRCT_TopBP1_rpt6; 1.
DR CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR CDD; cd17728; BRCT_TopBP1_rpt8; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 9.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035960; Secretoglobin_sf.
DR InterPro; IPR049542; TopBP1-like_BRCT0.
DR InterPro; IPR044737; TopBP1_BRCT_1.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 5.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF21298; TopBP1_BRCT0; 1.
DR SMART; SM00292; BRCT; 7.
DR SUPFAM; SSF52113; BRCT domain; 6.
DR SUPFAM; SSF48201; Uteroglobin-like; 1.
DR PROSITE; PS50172; BRCT; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 101..172
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 195..284
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 355..445
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 527..612
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 620..717
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 862..953
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1201..1293
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 976..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..996
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 163614 MW; F9A5D5999C6FA729 CRC64;
MSRNDKEPFL VKFLKSSENS ECFFKALESI KEFQSEEYLQ IITEEEALKI KENDKSLYIC
DPFSGIVFDH LKKLGCRIVG PQVVIFCMHH QQCVPRAEHP VYNMVMSDVT VSCTSLEKDK
REEVHKYVQM MGGRVYRDLN VSVTHLIAGE VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ
EKKIARYTDV NMEDFKCPIF LGCIICVTGL CSLDRKAVQR LTIKHGGQYM GQLKMNECTH
LIVQEPKGQK YECAKRWNVH CVTTQWFFDS VDKGFCQDES IYKTEPRPET KTVPDTSTPT
GQINTVDSRT LSDVSHISNI NASCINESMC NSVLNSKVEP TLENLENLDV SAFQAPEDLL
DGCRIYLCGF SGRKLDKLRR LINSGGGVRF NQLNEDVTHV IVGDYDDELK QFWDKSAHRP
HVVGAKWLLE CFSKGYMLPE EPYIHANYQP VEIPVSDQPE SKTALLKKNT NISKKDLAPD
EKHEQADEDL LSQYVNNNPT FLKDKEPQKK ENQSSVTRCL PDASTITEEG LFSQKSFLVL
GFSNENESNI ANIIRENAGK IVSLQSRIVA DYAVVPLLGC EVEATVGEVV TNTWLVTCID
YQTLIDPKSN PLFMPVPVMA GMTPLEDCVI SFSQCAGAEK DSLTFLANRL GASVQEFFVR
KSNAKKGMFA STHLVLKEPG GSKYDAAKKW NLPAVTISWL LETARMGKRA NESHFLIEKS
TKEDTPEHPV AHLETHRKTA VTPLDMNHFQ SKAFHAVISQ HTRQVSVSPP VGQPLQKEPS
LHLDTPSKFL SKDKLFKPSF DVKDALAALE TPGGPSQQKR KLSTPLSEVI VRNLKLALAN
SSRNAVALSA SPQLKDAQSE KVELDLLLKV VVCVSKKLSK KQGELNGIAA SLGADYRWSF
DETVTHFIYQ GRPNDTNREY KSVKERGVHI VSEHWLLECA QEYKHLPESL YPHTYNPKMS
LDISTVQDGR LSNSRLLSAD STTKDDEPDH LPVEENDIDN MTTNNKESAT SNGDGRNDSK
GALTQTLEMR ENFQKQLQEI MSATSIVKPQ GQRASLSRSG CNSASSTPDS TRSARSGRSR
VLEALRQSRQ TVPDVNTEPS QNEQIIWDDP TAREERARLA SNLQWPSCPT QYSELQGDIK
KLEDSPSQEP LRDSEIAERA PKHPISEELE TPVKDSHLIP TPQAPSIAFP LANPPVAPHP
REKVNLKKQY IFQLSSLNPQ ERIDYCHLIE KLGGLVIEKQ CFDPNCTHIV VGHPLRNEKY
LASVAAGKWV LHRSYLEACR TAGHFVPEED YEWGSSSILD VLTGINVQQR RLALAAMRWR
KKLQQRQESG IVEGAFSGWK VILYVDQSRE AGFKRLLQSG GAKVLPGHSV PLFKEATHLF
SDFNKLKPDD SGVNIAEAAA QNVYCLKTEY IADYLMQFDV SPPVNFCLCF LSFWCEIQKI
FTKTNVKELM MYVSF
//
