ID A0A452S5J6_URSAM Unreviewed; 813 AA.
AC A0A452S5J6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT6 {ECO:0000313|Ensembl:ENSUAMP00000027366.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027366.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027366.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A452S5J6; -.
DR Ensembl; ENSUAMT00000030588.1; ENSUAMP00000027366.1; ENSUAMG00000021182.1.
DR GeneTree; ENSGT01080000257420; -.
DR OMA; EPQMPAM; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10377; SH2_STAT6; 1.
DR CDD; cd16856; STAT6_CCD; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR028187; STAT6_C.
DR InterPro; IPR035857; STAT6_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF48; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF14596; STAT6_C; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 486..601
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 813 AA; 90597 MW; 66BD0423D4C64CE4 CRC64;
MSLWGLVSKM PPEKLQRLYV DFPQHLRHLL SDWLENQPWE FLVGSDTFCC NMASALLSAT
VQRLQASAGK QGEGSAILQH ISTLESIYQR DPLKLVATFR QILQGEKKAV MEQFRHLPMP
FHWKQEELKF NTALQRLQHR VGETRLLREA LQPGAEAGQV SLHSLIDAPA NGTGPSEALA
KLLQETVGEL EAAQALVLKR IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ
EVGAAGGELE PKARAVLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLR
FLGAPAKPPL VRADMVTEKQ ARELSMPQGP GTGAESTGEI INNTVALENS IPANCCSALF
KSLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLP IQLQDRVPFV VAERVPWEKM
CETLNLKFMA EVGTNRGLLP EHFLFLAQKI FNDNSLSMEA FQHRSVSWSQ FNKEILLGRG
FTFWQWFDGV LDLTKRCLRS YWSDRLIIGF ISKQYVTSLL LNEPDGTFLL RFSDSEIGGI
TIAHVIRGQD GSPQIENIQP FSAKDLSIRS LGDRIRDLAQ LKNLYPKKPK DEAFRSHYKP
EQMGKDGRGY VPATIKMTVE RDQPLPTLEP QMPTMVPAYD LGMAADSSMN MQLSPDMVSQ
VYPPHSHSIP SYQALSREDT LTAFPESHLQ MPPNLNQINL PFDQPHPQGL LPCPSQEHAV
STPEPLLCSD VTMAEDSCMN QSVGGFPQGT WVGEDMFPPL LPPTEQDLTK LLLEGQGESG
GGSLGTQPLL QPSHYGQSGI SMSHLDLRAN PSW
//
