ID A0A452S640_URSAM Unreviewed; 761 AA.
AC A0A452S640;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=LIM domain and actin binding 1 {ECO:0000313|Ensembl:ENSUAMP00000027583.1};
GN Name=LIMA1 {ECO:0000313|Ensembl:ENSUAMP00000027583.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027583.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027583.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452S640; -.
DR STRING; 9643.ENSUAMP00000027583; -.
DR Ensembl; ENSUAMT00000030824.1; ENSUAMP00000027583.1; ENSUAMG00000021327.1.
DR GeneTree; ENSGT00940000158313; -.
DR OMA; NQQVFHV; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0003785; F:actin monomer binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0030835; P:negative regulation of actin filament depolymerization; IEA:Ensembl.
DR GO; GO:0031529; P:ruffle organization; IEA:Ensembl.
DR CDD; cd09485; LIM_Eplin_alpha_beta; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR028740; EPLIN_Lim_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24206:SF57; LIM DOMAIN AND ACTIN-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR24206; OS06G0237300 PROTEIN; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 388..448
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 79..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 84838 MW; 51F9A41F2C71E78C CRC64;
MESAPFNRRQ WTSVSLRVTA KELSLVNKNK SSAIVEIFSK YQKAAEEANM EKRRSNTENL
PQHCRRGVLT VLKKKWENPA LGTESHTDSL RNGSAEVGHG GNQPAGEVAR SSASEAEADQ
EERAHPRPRF GSPPEALTQC PYPRTEGSER PKDHLKERKK MENCLGESRH EVGKPEISEN
TEAANKIEKY NVPLNRLKMM FEKGEPTQTK ILRSQSRSTG GRRISENSCS LDDLEIGPGQ
SSSSPFNAEK SESRRNLDFP RLSETSIKDR MAKYQAAVSK QSSSTNSTND LRANGGEIRT
HKLEQKENVP PDPEVCISHQ VGEKVSATEN SLAVRSTPAE DESRNSQVKS EVQQPVHPKP
LNPDARASSL SESSPPKAVK KFQAPARETC VECQKTVYPM ERLLANQQVF HVSCFRCSYC
NNKLTLGTYA SLHGRIYCKP HFNQLFKAKG NYDEGFGHRP HKDLWASKNE NEGILERPAQ
LPNAGETPQS PGVEDAPIAK VGVLTASMEA KASSQPEKED KPAETKKLKI AWPPPTELGS
SGSILEEGIK VSKPKWPPED EISKPEAPED VDLDLKKLRR SSSLKERSRP FTVAASFRTT
SVKSPKISSP PIRKGWSMSE QSEEFTGGMT AERKQVENAN TFEKNGSVGK TTWQNQESGG
GETGRRSKED HGFEMGSENL TENGANLDED DRNLNQQSPL EPTPTNWSSF ADNTSPKEFT
TQNQESEDVG FWEGEVVQEL SVEEQIKRNR YYDEEEEEDE E
//
