ID A0A452S6B8_URSAM Unreviewed; 812 AA.
AC A0A452S6B8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=RAS p21 protein activator 3 {ECO:0000313|Ensembl:ENSUAMP00000027663.1};
GN Name=RASA3 {ECO:0000313|Ensembl:ENSUAMP00000027663.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027663.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452S6B8; -.
DR Ensembl; ENSUAMT00000030917.1; ENSUAMP00000027663.1; ENSUAMG00000020235.1.
DR GeneTree; ENSGT00940000157953; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13371; PH_GAP1_mammal-like; 1.
DR CDD; cd05134; RasGAP_RASA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037774; RASA3_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR PRINTS; PR00402; TECBTKDOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..100
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 111..241
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 308..502
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 554..655
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 782..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 93177 MW; 4A144F25BC5F1421 CRC64;
ILNSWKGEAK NLPTYPGPNK MRDCYCTVNL DREEVFRTKI VEKSLCPFYG EDFYCEIPRS
FRHLSFYIFD RDVFRRDSII GKVAIQKEDL PKYHNRDTWF LLQHVDADSE VQGKVHLELR
LSEVITDTGV VCHKLATRIL ECQGLPIVNG QCDPYATVTL AGPYRSEAKK TKVKKKTNNP
QFDEVFYFEV GRPSRRSVSR WLFFRVDLWN ASNLKFGDEF LGELRVPLNV LRQSSSYEAW
YFLQPRDNGS KSLKPGDLGS LRLNVVYTED HVFSSDYYSP LRDLLLRSAD VEPVSASAAH
VLGEVCREKQ EAAVPLVRFF LHYGRVVPFI SAIANAEVQR TQDPNTIFRG NSLTSKCIDE
TMKLAGMHYL HVTLKPTIEE ICQSHKSCEI DPVKLKDGEN LENNMENLRQ YVDRIFTVIT
KSGVSCPTVM CDIFFSLREA AAKRFQDDLD VRYTAVSSFI FLRFFAPAIL SPNLFQLTPH
HTDPQTSRTL TLISKTIQTL GSLSKSKSAS FKESYMAAFY EFFNEQKYAD AVKNFLDLIS
SSGRRDPKSI EQPILLKEGF MIKRAQGRKR FGMKNFKKRW FRLTNHEFTY QKSKGDQPLC
SIPIENILAV EGLEEESFKM KNMFQVIQPE RALYIQANNC VEAKAWIDVL TKVSQCNKKR
LTVYHPSAYL NGHWLCCRAS SDTAPGCSPC TGGLPANIQL DIDGDRETER IYSLFNSYMS
KLEKMQEACG SRSVYDGPEQ EEYSTFIIDD PQETYKTLKQ VIAGVAALEQ EHAQYKRDKF
KKTKYGSQEH PIGDKSFQSY IRQQSETSTH SI
//
