ID A0A452S6C1_URSAM Unreviewed; 463 AA.
AC A0A452S6C1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Calcitonin gene-related peptide type 1 receptor {ECO:0000256|ARBA:ARBA00015885, ECO:0000256|RuleBase:RU368099};
DE Short=CGRP type 1 receptor {ECO:0000256|RuleBase:RU368099};
DE AltName: Full=Calcitonin receptor-like receptor {ECO:0000256|ARBA:ARBA00030562, ECO:0000256|RuleBase:RU368099};
GN Name=CALCRL {ECO:0000313|Ensembl:ENSUAMP00000027657.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027657.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027657.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together
CC with RAMP1 and receptor for adrenomedullin together with RAMP2 or
CC RAMP3. The activity of this receptor is mediated by G proteins which
CC activate adenylyl cyclase. {ECO:0000256|RuleBase:RU368099}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
CC {ECO:0000256|RuleBase:RU368099}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU368099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368099}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314, ECO:0000256|RuleBase:RU368099}.
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DR AlphaFoldDB; A0A452S6C1; -.
DR STRING; 9643.ENSUAMP00000027657; -.
DR Ensembl; ENSUAMT00000030908.1; ENSUAMP00000027657.1; ENSUAMG00000021347.1.
DR GeneTree; ENSGT00940000159898; -.
DR OMA; AIVICIY; -.
DR OrthoDB; 5345963at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:1903143; C:adrenomedullin receptor complex; IEA:Ensembl.
DR GO; GO:1990406; C:CGRP receptor complex; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:1990409; F:adrenomedullin binding; IEA:Ensembl.
DR GO; GO:0001605; F:adrenomedullin receptor activity; IEA:Ensembl.
DR GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; IEA:Ensembl.
DR GO; GO:0004948; F:calcitonin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0071329; P:cellular response to sucrose stimulus; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR CDD; cd15274; 7tmB1_calcitonin_R; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF21; CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR; 1.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR01351; CGRPRECEPTOR.
DR PRINTS; PR01350; CTRFAMILY.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU368099};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU368099};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU368099};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU368099};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368099};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368099};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Signal {ECO:0000256|RuleBase:RU368099, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU368099};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368099};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368099}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..463
FT /note="Calcitonin gene-related peptide type 1 receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019300094"
FT TRANSMEM 143..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 229..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 255..274
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 336..357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT DOMAIN 49..133
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 143..390
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 463 AA; 53477 MW; F81748A18577D751 CRC64;
MMEKKCILYL LLILPFFMIL DIAESEENIE DLSQLGVYTR NKIMTAQYEC YQKIMQDPIQ
QTEGIYCNRT WDGWLCWNDV AAGTESIQHC PDYFQDFDPS EKVTKICDQD GNWFRHPESN
RTWTNYTQCN VNTQEKVKTA LNLFYLTIIG HGLSIASLLI SLGIFFYFKS LSCQRITLHK
NLFFSFVCNS IVTIIHLTAV ANNQALVATN PVSCKVSQFI HLYLMGCNYF WMLCEGIYLH
TLIVVAVFAE KQHLIWYYFL GWGFPLIPAC IHAVARSLYY NDNCWISSDT HLLYIIHGPI
CAALLVNLFF LLNIVRVLIT KLKVTHQAES NLYMKAVRAT LILVPLLGIE FVLIPWRPEG
RIAEEIYDYI MHILMHYQGL LVSTIFCFFN GEVQAILRRN WNQYKIQFGN SFSHTDALRS
ASYTVSTISD GTGYSHDCPS EHLNGKSIHD IENVVLKPEK LYD
//
