ID A0A452S6W7_URSAM Unreviewed; 573 AA.
AC A0A452S6W7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Amyloid beta precursor protein binding family A member 3 {ECO:0000313|Ensembl:ENSUAMP00000027896.1};
GN Name=APBA3 {ECO:0000313|Ensembl:ENSUAMP00000027896.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027896.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027896.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452S6W7; -.
DR Ensembl; ENSUAMT00000031167.1; ENSUAMP00000027896.1; ENSUAMG00000021574.1.
DR GeneTree; ENSGT00940000160384; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF9; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 217..364
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 397..482
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 487..556
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 60599 MW; 2105CECEEA1BD7B1 CRC64;
MELLTTSQAP SGPPVMDLEE PRDTLSPSQD LTPNCQWDPV PGRSGSLSQM ELDGPGIEDL
VQQFEALPGD LVGLSPDGPP CPLHVATGHG LASQDVADAH GLLSAEAGRD DLLSLLHCQE
CPPSQSCPKE PLDPAPRPLQ PPEDPDGDTS APEWAEGASA EQGGNRSSSS SPEPWLETVP
LVTPEERPAS TQSPKTLVPY PALQEVPGPC DHEDLLDGVI FGAKYLGSTQ LVSERNPPPS
TRMAQAREAM DRVKAPDGET QPMTEVDLFV STKRVKVLTA DSQEALMDHA LQTISYIADI
GSVLVLMARR RLARRPAPQA RGHRLYKMLC HVFHSEDAQL IAQAIGQAFT VAYSQFLRES
GIDPNQVGAQ QSQGATGPGH LHNGDLDHFS NSENCREVCI EKRRGEGLGV ALVESGWGSL
LPTAVIANLL HGGPAERSGA LSIGDRLTAI NGTSLVGLPL AACQAAVREL KSQTVVTLSI
VHCPPVTTAI IRRPHAHQQL GFCVEDGIVC SLLRGGIAER GGVRVGHRII EINGHSVVAT
PHARIIELLT EAHTEVCGQR AGPGGPPAGA GPP
//
