ID A0A452S727_URSAM Unreviewed; 2747 AA.
AC A0A452S727;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RAN binding protein 2 {ECO:0000313|Ensembl:ENSUAMP00000027964.1};
GN Name=RANBP2 {ECO:0000313|Ensembl:ENSUAMP00000027964.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027964.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSUAMT00000031239.1; ENSUAMP00000027964.1; ENSUAMG00000020025.1.
DR GeneTree; ENSGT00940000154389; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR CDD; cd14684; RanBD1_RanBP2-like; 1.
DR CDD; cd13177; RanBD2_RanBP2-like; 1.
DR CDD; cd14685; RanBD3_RanBP2-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 6.
DR InterPro; IPR022011; IR1-M.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23138:SF169; E3 SUMO-PROTEIN LIGASE RANBP2; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF12185; IR1-M; 2.
DR Pfam; PF00638; Ran_BP1; 3.
DR Pfam; PF00641; zf-RanBP; 6.
DR SMART; SM00160; RanBD; 3.
DR SMART; SM00028; TPR; 2.
DR SMART; SM00547; ZnF_RBZ; 6.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 5.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50196; RANBD1; 3.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 6.
DR PROSITE; PS50199; ZF_RANBP2_2; 6.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT REPEAT 52..85
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1159..1295
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 1339..1369
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1403..1432
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1467..1496
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1531..1560
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1595..1624
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1654..1683
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 1807..1943
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT DOMAIN 2104..2240
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT REGION 756..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1622..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1985..2019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2068..2102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2358..2387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2402..2423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2594..2625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1785..1799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2068..2090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2361..2382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2406..2422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2594..2609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2747 AA; 305359 MW; A93494BF31B6F0F0 CRC64;
LELRKNESQR YIFESQYTIS RFYFAKLYYE VKEYDLAKKY ISAYINVQER DPKAHRFLGL
LHEVEENIDK AVESYKRSVE LNPTQKDLVL KIAELLCKND VTDGRAKYWV ERAAKLFPGS
PAIYKLKEQL LDCKGEDGWN KLFDLIQSEL YARPDDVYVN IRLVELYRSN KRLKDAVGHC
HEAEKNIALR SSLEWNSCVV QTLKEYLESL QCLESDKSNW QTTNKDLLLA YANLMLLTLS
TRDVQESREL LESFDSALQS VKSCVGGNDE LSTTFLEVKG HFYMHAGSLL LKMGQHSEVQ
WRALSELATL CYLIAFQVPR PKIKLIKGEV GQNLVEMMAY DRLSQSGHML LNLSRDKQDF
LKEVVESFAN KSGQSALYDA LFSSQSPKDR SFLGNDDIGN IDVQAPEPDD LARYDVGAIR
AHNGSLQHLT WLGLQWNSLS ALPAVRKWLK QLFHHLPQET SRLETNAPES ICILDLEVFL
LGVIYTSHLQ LKEKCSSHYS FYQPLCLPLP VCKQLCTERQ KSWWDAVCNL IHRKTVPGTT
AKLRILVQHD INTLRGQEKH GLQPALLVHW AKCLQKTGSG LNSFYDQREY IGRSVHYWKK
VLPMLKTIKK KSSIPEPTDP LFKHFHSADI QASEVDEYEE EAHITFAILD VVNGNIEDAM
TAFESIKNVV SYWNLALIFH RKAEDIENDV LSPEEQEECK NYLRKARDYL IKILDDSDSS
LSVAKKLPVP LESVKEMLNS VMQELDDYSE GGPLYKNGSL RNADSEIKHS TPSPSIYSLS
PSKSYKYSPK TPPRWAEDQN SLLKMICQQV EAIKKEMQEL KLHSSNSGSP HRWPSENYGP
DSVPDGYQGS QTFHGAPLTV ATTGPSVYYS QSPAYNSQYL LRPAANVTPT KGPVYGMNRL
PPQQHIYAYS QQMHTPPVQS SSACMFSQEM YGPPLRFESP ATGILSPRGD DYFNYNVQQT
STNPPLPEPG YFTKPPVATH ASRSAESKVI EFGKTNFVQP MPGEGIRPSL TAPAHTTQPT
PFKFNSNFKS NDGDFTFSSP QVVTQPPSAA YNNNESLLGL LTSDKPLQGD GYSGPKATQT
IGPRNTFSFG SKNVPGISFT ENMGPNQQKN SGFRRSDDMF TFHGPGKSVF GTPAPELANK
SHETDGGSAH GDDDDDGPHF EPVVPLPDKI EVKTGEEDEE EFFCNRAKLF RFDAESKEWK
ERGIGNVKIL RHKTSGKIRL LMRREQVLKI CANHYISPDM KLTPNAGSDR SFVWHALDYA
DELPKPEQLA IRFKTPEEAA LFKCKFEEAQ NILKALGANV ATATNQAMRI VKEPTSHDNK
DICKSDAGNM NFEFQIAKKE GSWWHCNSCS LKNAATAKKC VSCQNLNPNK KELLGPPLVE
TVSGLTVGPE NTPDRFASMT PKKEGHWDCS ICLVRNEPAV SRCVACQNAK AANKSGSSFV
QQASFKFGQG DLPKSVNSDF RSVFSTKEGQ WDCSVCLVQN EGSSTKCAAC QNPRKQSLPT
SSVSASASFK FGTSEISKTP KSGFEDMFAK KEGQWDCSCC SLRNEASATV CVACQNPGKL
SLSTSAGPVP ASFKFSTSET SKAPKSGFEG MFTKKEGQWD CSVCLVRNEA SATTCVACQN
PSKQNQPTSA VLAPASSDTG KPPKSGFEGM FTKKEGQWDC SVCLVRNEAS ATTCVACQNP
SKQNQPTSAV LAPASSDTCK LNDSSGSQVG TGFKKGFSFS DISGQKNGSG VIFGQTGSTF
TFADLAKSTS GEGFQFGKKD PNFKGFSGAG EKLFSSQSGK MADKADTSAD LEKDDDAYRT
EDSDDIHFEP VVQMPEKVEL VTGEEDEKVL YSQRVKLFRF DAEISQWKER GLGNLKILKN
EVNGKLRMLM RREQVLKVCA NHWITTTMNL KPLSGSDRAW MWLASDFSDG DAKLEQLAAK
FKTPELAEEF KQKFEECQRL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS GLKDFKTFLT
NDQTKVTDGE SESSDAGAAS ACDTTSKPNP ENTGPTLEWD NYDLREDALD DSVGSSSVHA
SPLASSPVRK NLFRFGESTT GFNFSFKSAL SPSKSPAKLN QSGTSVGTDE ESDVTQEEER
DGQYFEPVVP LPDLVEVSSG EENEQVVFSH RAKLYRYDKD VGQWKERGIG DIKILQNYDN
KQVRIVMRRD QVLKLCANHR ITPDMTLQNM KGTERVWVWT ACDFADGERR VEHLAVRFKL
QDIADSFKKI FDEAKIAQEK NSLIAPHVSR SATPRESPCG KIAVAVLEET TRERTDLIQG
DDTADATSEV GEASSTSEAT TKAVVSPPKF VFGSESVKSI FSSEKSKPFA FGNSSATGSL
FGFSFNAPLK NSSEISSVVK SGSERKVEPD CEELKNSDSR QSSDGKVKNL FAFPKEESST
NYTFKTPEKA KEKEKPEDPP SDDDVLIVYE LTPTPEQKAL ASKLQLPPTF FCYKNKPDYI
SEEEEDDEDF ETAVKNLNGK LYLDDSEKCR PLEEKLTDNE KECVIVWEKK PTVEEKAKAD
TLKLPPTFFC GVCSDTDEDN GNGEDFQSEF QKVQDSQKSQ NAEITSTTDS VYTSGTTVTV
PFLCKSEEPD FITKSVSSPP ISSGTVDRPV DLSTRKENDA DSTSQVESKT VSFGFGSSTG
LSFADLASSN SGDFAFGSKD KNFQWANTGA AVFGAQSTSK VGEDEDGSDE EVVHNEDIHF
EPIVSLPEVN IKEWNNYVFP YVFRISCFHN IILGVKKYPG APGWHSG
//
