ID A0A452S731_URSAM Unreviewed; 875 AA.
AC A0A452S731;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Tight junction protein 3 {ECO:0000313|Ensembl:ENSUAMP00000027917.1};
GN Name=TJP3 {ECO:0000313|Ensembl:ENSUAMP00000027917.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000027917.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000027917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A452S731; -.
DR Ensembl; ENSUAMT00000031189.1; ENSUAMP00000027917.1; ENSUAMG00000021580.1.
DR GeneTree; ENSGT00940000160036; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005420; ZO-3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF11; TIGHT JUNCTION PROTEIN ZO-3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01600; ZONOCCLUDNS3.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 11..93
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 186..263
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 457..531
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 643..743
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 97..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 95784 MW; 427715A1A2B44E84 CRC64;
MEELTIWEQH TATLCKDPRR GFGIAVSGGR DRPHGSVVVS DVVPGGPAEG RLQTGDHIVM
VNGVSMENVT STFAIQILKT CTKVANITVK RPRKIQLPTA KASASGRGHQ DSDEADHGQG
YEGDTSSGSG RSWGERSRRP RAGRRSRAGS HGRRSPAGNS EANGLALVSG FKRLPRQDVH
MRPVKSVLVR RRESDEFGVT LGSQIFIKHI TDSGLAARNR GLQEGDLILQ INGVSSENLS
LSDTRRLIEK SEGKLTLLVL RDRGQFLVNI PPAVSDSDSS LLDDISDLGS ELSQAPPSHV
PPPPQHVQRN LDATALTVSR PRCLGHGLGR VVPSWPVLPP PHLSPAYTRF IILPTFSLLP
VLTPSPCKRG ATSAPRRPPP GSGLCPGAEL GCPAEGVPRA TSHLAPPSRQ VNDVPFRNLT
REEAVQFLLG LPPGEDVELV TQRKQDIFRR MVQSRVGDSF YIRTHFELEA SPPSGLGFTR
GDVFHVLDTL CPGPGQSRAR GGHWLAVRMG RDLREQERGI IPNQSRAEQL ASLEEAQRAV
GAGSGASVGS SARAEFWRLR GLRRGAKKTT HRSREDLSAL TRQGHYPPYE RVVLREASFK
RPVVILGPVA DIAMQKLTAE MPDQFEIADS VLRTDSPSKV IKLDTVRVIA EKNKHALLDV
TPSAVERLNY VQYYPIVVFC APESRPALKA LRQWLAPASR RSSRRLYAQA QKLRKHSEHL
FTATIPLHGT SDSWYQELKA IIREQQTRPI WTAEDQLDNS SEDNLELPHR GLADSSADLS
CDSRVNSDYE TDGEGYTDGE GGPHTDVDEG PPAPALARSS EPVGCSSSQF LSLWGKRQDS
VRTYGREALK KKFTRAQDTE SSDEDGYDWG PATDL
//
