ID A0A452S865_URSAM Unreviewed; 245 AA.
AC A0A452S865;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Tropomyosin alpha-1 chain {ECO:0000256|ARBA:ARBA00041188};
DE AltName: Full=Alpha-tropomyosin {ECO:0000256|ARBA:ARBA00042447};
DE AltName: Full=Tropomyosin-1 {ECO:0000256|ARBA:ARBA00042056};
GN Name=TPM1 {ECO:0000313|Ensembl:ENSUAMP00000028404.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000028404.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000028404.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the tropomyosin family.
CC {ECO:0000256|ARBA:ARBA00009036, ECO:0000256|RuleBase:RU004515}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSUAMT00000031723.1; ENSUAMP00000028404.1; ENSUAMG00000021959.1.
DR GeneTree; ENSGT01030000234542; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 2.
DR InterPro; IPR000533; Tropomyosin.
DR PANTHER; PTHR19269; TROPOMYOSIN; 1.
DR PANTHER; PTHR19269:SF80; TROPOMYOSIN ALPHA-1 CHAIN; 1.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 28409 MW; 2E76DB4BC3E817E8 CRC64;
MAGSSSLEAV RRKIRSLQEQ ADAAEERAGS LQRELDYERK LREXAEADVA SLNRRIQLVE
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE
DADRKYEEVA RKLVIIESDL ERAEERAELS ESKCAELEEE LKTVTNNLKS LEAQAEKYSQ
KEDKYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNQLKL
ALNED
//
