ID   A0A452S9B1_URSAM        Unreviewed;       606 AA.
AC   A0A452S9B1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Solute carrier family 53 member 1 {ECO:0000256|ARBA:ARBA00035271};
DE   AltName: Full=Phosphate exporter SLC53A1 {ECO:0000256|ARBA:ARBA00035512};
GN   Name=XPR1 {ECO:0000313|Ensembl:ENSUAMP00000028809.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000028809.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000028809.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823,
CC         ChEBI:CHEBI:43474; Evidence={ECO:0000256|ARBA:ARBA00035090};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32824;
CC         Evidence={ECO:0000256|ARBA:ARBA00035090};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
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DR   AlphaFoldDB; A0A452S9B1; -.
DR   Ensembl; ENSUAMT00000032164.1; ENSUAMP00000028809.1; ENSUAMG00000022061.1.
DR   GeneTree; ENSGT00500000044895; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14477; SPX_XPR1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 2.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        212..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..152
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          344..553
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
FT   REGION          578..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          45..72
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        585..606
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   606 AA;  70935 MW;  4CD445F70A01B711 CRC64;
     LYRLLFSLQE QVLMIFTDED TVKRYFAKFE EKFFQTCEKE LAKINTFYSE KLAEAQRRFA
     TLQNELQSSL DAQKESTGVT TLRQRRKPVF HLSHEERVQH RNIKDLKLAF SEFYLSLILL
     QNYQNLNFTG FRKILKKHDK ILETSRGADW RVAHVEVAPF YTCKKINQLI SETEAVVTNE
     LEDGDRQKAM KRLRVPPLGA AQPAPAWTTF RVGLFCGIFI VLNITLVLAA VFKLETDRSI
     WPLIRIYRGG FLLIEFLFLL GINTYGWRQA GVNHVLIFEL NPRSNLSHQH LFEIAGFLGI
     LWCLSLLACF FAPISVIPTY VYPLVLYGFM VFFLINPTKT FYYKSRFWLL KLLFRVFTAP
     FHKVGFADFW LADQLNSLSV ILMDLEYMIC FYSFELKWDE SGGLLPNNSE ERGHSDTMVF
     FYLWIVFCVI SSCYTLIWDL KMDWGLFDKN AGENTFLREE IVYPQKAYYY CAIIEDVILR
     FAWTVQISIT SMTLSPHSGD IIATVFAPLE VFRRFVWNFF RLENEHLNNC GEFRAVRDIS
     VAPLNADDQT LLEQMMDQDD GVRNRQKNRP WKYSQSISLR RPRLASQSKA RDTKVLIEDT
     DDEANT
//