ID A0A452S9G6_URSAM Unreviewed; 2609 AA.
AC A0A452S9G6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Filamin C {ECO:0000313|Ensembl:ENSUAMP00000028906.1};
GN Name=FLNC {ECO:0000313|Ensembl:ENSUAMP00000028906.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000028906.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000028906.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR Ensembl; ENSUAMT00000032275.1; ENSUAMP00000028906.1; ENSUAMG00000021311.1.
DR GeneTree; ENSGT00940000153588; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 36..142
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 159..261
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 269..367
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 368..455
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 456..552
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 553..645
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 649..745
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 746..848
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 849..947
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 948..1043
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1044..1136
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1137..1231
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1232..1331
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1332..1424
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1425..1520
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1521..1617
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1630..1721
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1750..1819
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1819..1911
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1909..1998
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2001..2093
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2091..2190
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2193..2285
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2287..2380
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2384..2476
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2514..2608
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 977..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2609 AA; 277873 MW; 2A7B9AC986166D06 CRC64;
MMNNSGYSEA ALGLGDEVDD MPSTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVGKRLTDL
QRDLSDGLRL IALLEVLSQK RMYRKFHPRP NFRQMKLENV SVALEFLERE HIKLVSIDSK
AIVDGNLKLI LGLIWTLILH YSISMPMWED EDDEDARKQT PKQRLLGWIQ NKVPQLPITN
FNRDWQDGKA LGALVDTLQR LCPDWEAWDP NQPVENAREA MQQADDWLGV PQVIAPEEIV
DPNVDEHSVM TYLSQFPKAK LKPGAPVRSK QLNPKKAIAY GPGIEPHGNT VLQPAHFTVQ
TVDAGLGEVL VYIEDPEGHT EEAKVVPNND KNRTYAVSYV PKVAGLHKVT VLFAGQNIER
SPFEVNVGMA LGDPVGNVAN KPTYFDIYTA GAGTGDVAVV IVDPQGRRDT VEVALEDKGD
STFRCTYRPV MEGPHTVHVA FAGAPITRSP FPVHVAEACN PNACRASGRG LQPKGVRVKE
VADFKVFTKG AGSGELKVTV KGPKGTEEPV KVREAGDGVF ECEYYPVVPG KYVVTITWGG
YAIPRSPFEV QVSPEAGAQK VRAWGPGLKT GQVGKSADFV VEAIGTEVGT LGFSIEGPSQ
AKIECDDKGD GSCDVRYWPT EPGEYAVHVI CDDEDIRDSP FIAHIQPAAP DCFPDKVKAF
GPGLEPTGCI VDKPAEFTID ARAAGKGDLN LYAQDADGCP VNITVIPNGD GTFRCSYVPT
KPIKHTIIVS WGGVNVPKSP FRVNVGEGSH PERVKVYGPG VEKTGLKANE PTYFTVDCSE
AGQGDVSIGI KCAPGVVGPA EADIDFDIIK NDNDTFTVKY TPPGAGRYTI MVLFANQEIP
ASPFHIKVDP SHDASKVKAE GPGLNRTGVE VGKPTHFTVL TKGAGKAKLD VHFAGAAKGE
AVRDFEIIDN HDYSYTVKYT AVQQGNMAVT VTYGGDPVPK SPFVVNVAPP LDLSKVKVQG
LNSKVAVGQE QAFSVNTRGA GGQGQLDVRM TSPSRRPIPC KLEPGGGAET QAVRYMPPEE
GPYKVDITYD GHPVPGSPFA VEGVLPPDPS KVCAYGPGLK GGLVGTPAPF SIDTKGAGTG
GLGLTVEGPC EAKIECQDNG DGSCAVSYLP TEPGEYTINI LFAEAHIPGS PFKATIRPVF
DPSKVRASGP GLERGKAGEA ATFTVDCSEA GEAELTIEIL SDAGVKAEVL IHNNADGTYH
ITYKPAFPGT YTITIKYGGH PVPKFPTRVH VQPAVDTSGI KVSGPGVEPH GVLREVTTEF
TVDARSLTAT GGNHVTARVL NPSGAKTDTY VTDNGDGTYR VQYTAYEEGV HLVEVLYDEV
AVPKSPFRVG VTEGCDPSRV RAFGPGLEGG LVNKANHFTV ETRGAGTGGL GLAIEGPSEA
KMSCKDNKDG SCTVEYIPFT AGDYDVNITF GGRPIPGSPF RVPVKDVVDP GKVKCSGPGL
GAGVRARVPQ TFTVDCSQAG RAPLHVAVLG PTGVAEPVEV LDNGGGTHTV HYTPATDGPY
TVAVKYADQE VPRSPFKIKV LPAHDASKVR ASGPGLNASG IPASLPVEFT IDARDAGEGL
LTVQILDPEG KPKKANIRDN GDGTYTVSYL PDMSGRYTIT IKYGGDEIPY SPFRIHALPT
GDASKCLVTV SIGGHGLGAC LGPRIQIGEE TVITVDAKAA GKGKVTCTVS TPDGAELDVD
VVENHDGTFD IYYTAPEPGK YVITIRFGGE HIPNSPFHVL VTDDCSSPLP QATEEPVVPA
EPMESMLRPF NLVIPFTVQK GELTGEVRMP SGKTARPNIT DNKDGTITVR YAPTEKGLHH
MGIKYDGNHI PGSPLQFYVD AINSRHVSAY GPGLSHGMVN KPATFTIVTK DAGEGGLSLA
VEGPSKAEIT CKDNKDGTCT VSYLPTAPGD YSIIVRFDDK HIPGSPFTAK ITGDDSMRTS
QLNVGTSTDV SLKITESDLS LLTASIRAPS GNEEPCLLKR LPNRHIGISF TPKEVGEHVV
SVRKSGKHVT NSPFKILVGP SEIGDASKVR VWGKGLSEGQ TFQVAEFIVD TRNAGYGGLG
LSIEGPSKVD INCEDMEDGT CKVTYCPTEP GTYIINIKFA DKHVPGSPFT VKVTGEGRMK
ESITRRRQAP SIATIGSTCD LNLKIPGEAS SQDMTAQVTS PSGKMEAAEI VEGEDSAYSV
RFVPQEMGPH TVTVKYRGQH VPGSPFQFTV GPLGEGGAHK VRAGGTGLER GVAGVPAEFS
IWTREAGAGG LSIAVEGPSK AEIAFEDRKD GSCGVSYVVQ EPGDYEVSIK FNDEHIPDSP
FVVPVASLSD DARRLTVTSL QETGLKVNQP ASFAVQLNGA RGVIDARVHT PSGAVEECYV
SELDSDKHTI RFIPHENGVH SIDVKFNGAH IPGSPFKIRV GEQSQAGDPG LVSAYGPGLE
GGTTGVSSEF IVNTLNAGSG ALSVTIDGPS KVQLDCRECP EGHVITYTPM APGNYLIAIK
YGGPQHIVGS PFKAKVTGPR LSGGHSLHET STVLVETVTK SSSSRGSSYS SIPKFSSDAS
KVVTRGPGLS QAFVGQKNSF TVDCSKAGTN MMMVGVHGPK TPCEEVYVKH MGNRVYNVTY
TVKEKGDYIL IVKWGDESVP GSPFKVNVP
//
