ID   A0A452S9S8_URSAM        Unreviewed;      1535 AA.
AC   A0A452S9S8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Dedicator of cytokinesis 7 {ECO:0000313|Ensembl:ENSUAMP00000028994.1};
GN   Name=DOCK7 {ECO:0000313|Ensembl:ENSUAMP00000028994.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000028994.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000028994.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   Ensembl; ENSUAMT00000032370.1; ENSUAMP00000028994.1; ENSUAMG00000020665.1.
DR   GeneTree; ENSGT00940000155661; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08696; C2_Dock-C; 1.
DR   CDD; cd11703; DHR2_DOCK7; 1.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR037808; C2_Dock-C.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR   PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 1.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          1..163
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   DOMAIN          1075..1509
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000259|PROSITE:PS51651"
FT   REGION          321..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1535 AA;  173910 MW;  D388B5DE462921E9 CRC64;
     YIYPQSLNFA NRQGSARNIT VKVQFMYGED PSNAMPVIFG KSSCSEFSKE AYTAVVYHNR
     SPDFHEEIKV KLPATLTDHH HLLFTFYHVS CQQKQNTPLE TPVGYTWIPM LQNGRLKTGQ
     FCLPVSLEKP PQAYSVLSPE VPLPGMKWVD NHKGVFNVEV VAVSSIHTQD PYLDKFFALV
     NALDEHMFPV RIGDMRIMEN NLENELKSSI SALNSSQLEP VVRFLHLLLD KLILLVVRPP
     VIAGQIVNLG QASFEAMASI INRLHKNLEG NHDQHGRNSL LSSYIYYVFR LPNTYPNSPS
     PGSVHYATMA RSAVRPASLN LNRSRSLSNS NPDISGTPTS PDDEVRSIIG SKGLDRSNSW
     VNTGGPKAVP WGSNPSPSAE STQVVFILEV SLLAADLFHE ELALQWVVCS GSVRESALQQ
     AWFFFELMVK SMVHHLYFND KLDAPRKSRF PERFMDDIAA LVSTIASDIV SRFQKDTEMV
     ERLNTSLAFF LNDLLSVMDR GFVFSLIKTC YKQVSSKLYS LPNPSVLVSL RLDFLRIVCS
     HEHYVTLNLP CSLLTPPASP SPSVSSATSQ SSGFSTNVQD QKIANMFELS VPFRQQHYLA
     GLVLTELAVI LDPDAEGLFG LHKKVINMVH NLLSSHDSDP RYSDPQTKAR VAMLYLPLIG
     IIMETVPQLY DFTETHNQRG RPICIAPDDY ESESGSMISQ TVAMAIAGTS KLPLIGVSHS
     TVLYFQSGRQ HTTFSAESSR SLLICLLWVL KNADETVLQK WFTDLSVLQL NRLLDLLYLC
     VSCFEYKGKK VFERMNSLTF KKSKDMRAKL EEAILGSIGA RQEMVRRSRG HAFGSQENLR
     WRKDMTHWRQ NTEKLDKSRA EIEHEALIDG NLATEANLII LDTLEIVVQT VSVTESKESI
     LGGVLKVLLH SMACNQSAVY LQHCFATQRA LVSKFPELLF EEETEQCADL CLRLLRHCSS
     SIGTIRSHAS ASLYLLMRQN FEIGNNFARV KMQVTMSLSS LVGTSQNFNE EFLRRSLKTI
     LTYAEEDLEL RETTFPDQVQ DLVFNLHMIL SDTVKMKEHQ EDPEMLIDLM YRIAKGYQTS
     PDLRLTWLQN MAGKHSERSN HAEAAQCLVH SAALVAEYLS MLEDRKYLPV GCVTFQNISS
     NVLEESAVSD DVVSPDEEGI CSGKYFTESG LVGLLEQAAA SFSMAGMYEA VNEVYKVLIP
     IHEANRDAKK LSTIHGKLQE AFSKIVHQDG KRMFGTYFRV GFYGTKFGDL DEQEFVYKEP
     AITKLAEISH RLEGFYGERF GEDVVEVIKD SNPVDKCKLG PNKAYIQITY VEPYFDTYEM
     KDRITYFDKN YNLRRFMYCT PFTLDGRAHG DLHEQFKRKT ILTTSHAFPY IKTRVNVTHK
     EEIILTPIEV AIEDMQKKTQ ELAFATHQDP ADPKMLQMVL QGSVGTTVNQ GPLEVAQVFL
     SEIPSDPKLF RHHNKLRLCF KDFTKRCEDA LRKNKSLIGP DQKEYQRELE RNYHRLKEAL
     QPLINRKIPQ LYKAVLPVTC HRDSFSRMSL RKMDL
//