ID   A0A452S9Y7_URSAM        Unreviewed;       751 AA.
AC   A0A452S9Y7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Thrombospondin type 1 domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000029100.1};
GN   Name=THSD1 {ECO:0000313|Ensembl:ENSUAMP00000029100.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000029100.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000029100.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452S9Y7; -.
DR   STRING; 9643.ENSUAMP00000029100; -.
DR   Ensembl; ENSUAMT00000032489.1; ENSUAMP00000029100.1; ENSUAMG00000022439.1.
DR   GeneTree; ENSGT00390000013335; -.
DR   OMA; SHPRNSH; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR   GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR038877; THSD1.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR16311; THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1; 1.
DR   PANTHER; PTHR16311:SF3; THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        313..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          343..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..370
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..564
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..585
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   751 AA;  81939 MW;  534050FB6EED5408 CRC64;
     MFLEAADNST PVRQGEQSAF LKVDWPVFHI DLNRTSQAAE GTFQVGLFTN QPLCSFPADQ
     PDILVDVAFT NSLPEARTSP GQPLEIRTSK RTELSQGQWV EFGCAPVGPE AYVTVVLKLL
     GRDSVITSTG PIDLAQKFGY KLVLAPELTC ESGVEVLVRP PPCVFVQGVI TVFKEAPRRP
     GERTIQLAEN SLTLGERRTV FNCTLFDMGR NKYCFDFGVS SRSHFSAKER ECMLIQRNIE
     TWGLWQPWSQ CSTTCGDGVR ERRRVCLTSF PSRPGCPGMS SETSLCSLEE CAAFQPSSAS
     PLQPQGPVKS NNIVTVTGIS LCLFIIVATV LITLWRKFGR APKCSTPARH NSIHSPSFRK
     NSDEENICEL SEPRGSFSDG GDGPAGGPGD AGIPLTYRRS VPLSPEDDAS GSESVQSTAQ
     KIIPPLFSYR LAQQQLKEMK KKGLTETTKV YHVSQSPLTD TAIDGAAVPP LDLEGPEEAA
     AGKFRIKAPF PEQPAGGAAP RPPSRLDLPA CPASCAVSPS QAVIRKSALR HVGGRGALPE
     RSHPRGSHFR RTASFHEAKQ ARPFRERSMS TLTPRQAPAY SSRTRTWDQA EDRFRPQSRG
     AAPFPEKPDP FQGAGATRGP LSPPPKSYTL GQPARKPDLG DCQAAFTAGV ERTEPHRARR
     GPSPSHRGVS RKQPSPTVPK DGYQRVSPLS PSQCRKDKCQ SFPAHPEFAF YDNTSFGLTE
     AEQRMLDLPG YFGSNEEDET TSTLSVEKLV I
//