ID A0A452SB48_URSAM Unreviewed; 689 AA.
AC A0A452SB48;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Inhibitor of nuclear factor kappa B kinase subunit epsilon {ECO:0000313|Ensembl:ENSUAMP00000029563.1};
GN Name=IKBKE {ECO:0000313|Ensembl:ENSUAMP00000029563.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000029563.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000029563.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452SB48; -.
DR Ensembl; ENSUAMT00000032986.1; ENSUAMP00000029563.1; ENSUAMG00000022756.1.
DR GeneTree; ENSGT00950000182937; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd17128; Ubl_IKKE; 1.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041309; TBK1_CCD1.
DR InterPro; IPR041087; TBK1_ULD.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF10; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18394; TBK1_CCD1; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..315
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 689 AA; 77116 MW; C4E14288556AA47B CRC64;
MQSTANYLWH TDDLLGQGAT ASVYKARNKK SGELVAVKVF NTASYLRPHE VQVREFEVLR
KLNHQNIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLES PENAFGLPEE EFLVVLRCVV
AGMNHLRENG IVHRDIKPGN IMRLMGEEGQ SIYKLTDFGA ARELDDDEKF VSVYGTEEYL
HPDMYERAVL RKPQQKTFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEMMYRITTE
KPAGAIAGTQ RQENGPLEWS YSLPITCRLS TGLQTQLVPI LANILEVEQA KCWGFDQFFA
ETSDILQRVV VHVFSLSQAV LHHVYIHAHN TIAIFLEAVY EQTQVAPQHQ EYLFEGHLCV
LEPSLSAQHI AHTTSSSPLT LFSTASETPK GLAFRDPAQD IPKFFPKVDL QSDYTTSKVR
GGAGEAPTQP CGRALGPLEV LQAMGRRTLE VVRVALLFLS SSLGTERFSS VSGTPEIEEV
KRVTELKSRL RALAEALSRC SHRITETQSR LSNLSSELLK NRDQVHADRS IQKIQCCLDK
MNLIYKQFKK SRMRPGLGYN EEQIHKLDKV NFSRLAKRLL KVFQEKCVQK YQTSLVTHGM
WMREVHETRN RLRMVGCSVA AHNTEAQGVQ ESLSKVLGGG LPGEGGWQDN SGLSADTSLA
SASDSMRELC DEMKLLAFDL QDNNRIIEG
//
