ID   A0A452SB49_URSAM        Unreviewed;      1017 AA.
AC   A0A452SB49;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSUAMP00000029564.1};
GN   Name=ARHGEF10L {ECO:0000313|Ensembl:ENSUAMP00000029564.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000029564.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000029564.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452SB49; -.
DR   Ensembl; ENSUAMT00000032987.1; ENSUAMP00000029564.1; ENSUAMG00000022614.1.
DR   GeneTree; ENSGT00940000153798; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          272..354
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          121..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          417..450
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..22
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1017 AA;  109550 MW;  F2B72E17F6D5A643 CRC64;
     PEAEDDPGEA FEFDDSDDDE DTSTGLGVPG VAPDKDIDDA PLIHLDSAPI TGKVFLGALG
     PPISGAPPVV SNGDAADAAL SGVRRSSWKR KSSRRIDRFT FPALEEDVIY DDVPCENLDA
     HQPGKPPPRF PAAFGGPAGG GGGARGGSPS ISPSRPTGQL SPDLTRLKER CARTKRDILA
     LRAGGRDMQA LKHKYDCKMT QLMKAAKSGT KDGLEKTRIA VMRKVSFLHR KDVLGDSEEE
     DMGLLEVSVT DIKPPAPELG PMPEGLSPQQ VVRRHILGSI VQSEGSYVES LKRVLQDYRN
     PLMEMEPKVL SARKCQAVFF RVKEILHCHS MFQIALSSRV AEWDATEKIG DLFVASFSKS
     MVLDVGAPSA PVSAGGGRVR PGSQARGGSA GARFSALGLS ASWQDMLKNT PRGHPDRLSL
     QLALTELETL AEKLNEQKRL ADQVAEIQQL TKSVSDRSSL NKLLTSGQRQ LLLCETLTET
     VYGDRGQLIK SKERRVFLLS DMLVCANINF KPANHRGQLE ISSLVPLGPK YVVKWNTALP
     QVQVVEVGQE GGSYDKDNVL IQHAGAKKAS AAGQAQNKVY FGPPRLFQEL QDLQKDLAVV
     EQITFLISTL HGTYQNLNMT VAQDWCLALQ RLMRVKEEEI HSANKCRLRL LLPGKPDKSG
     RPISFMVVFI TPNPLSKISW VNRLHLAKIG LREENQPGWL CPDEDKKSKA PFWCPILACC
     IPAFSSRGLS LQLGALVHSP VSCPLLGFSA VSTSLPQGYL WVGGGQEGAG GQVEIFSLNR
     PSPRTVKSFP LAAPVLCMEY IPEPEEGESG DESHVATDPS ATVHPTICLG LRDGSILVYG
     SVDTGTQCLA TCRSPGLQPV LCLRHNPFHL FAGLQDGTLA AYPRTSGGVP WDLESPPVCL
     TVGPGPIRTL LSLEDAVWAS CGPRVTVVDA TSLQTQVLAL PCGSRPPASR PSVGLPLVVP
     SHALPGTVLS LCCVSGIRES LSRSTVGPKS LLGPSLYPSM HPWGCLEGKG PDHWAEL
//