ID A0A452SCD4_URSAM Unreviewed; 550 AA.
AC A0A452SCD4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Keratin 75 {ECO:0000313|Ensembl:ENSUAMP00000030013.1};
GN Name=KRT75 {ECO:0000313|Ensembl:ENSUAMP00000030013.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030013.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452SCD4; -.
DR STRING; 9643.ENSUAMP00000030013; -.
DR Ensembl; ENSUAMT00000033486.1; ENSUAMP00000030013.1; ENSUAMG00000023063.1.
DR GeneTree; ENSGT00940000155862; -.
DR OMA; SIKKQCS; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF13; KERATIN, TYPE II CYTOSKELETAL 75; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 149..462
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 146..187
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 232..280
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 360..440
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 550 AA; 59717 MW; C42E28FC4E0B9FEE CRC64;
MSRQSSITFQ TGSRRSFSTA SATTPAAGRS RFSSVSVARC TGGGAGLGRI SGAGAGFGSR
SLYSLGGTRR VSIGRCGGSF RSGFGGRASS GFGVSSGFGY GGAAGGGYGA SGFPVCPPGG
IQEVTVNQSL LTPLNLQIDP AIQRVRKEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK
WELLQEQGSK TVRQNLEPFF DAYITDLRRQ LDGVTTERGR LDAELRNMQD VVEDFKVRYE
DEINKRTTAE NEFVALKKDV DAAYMNKVEL EAKVNSLTDE INFFRMFFEA ELSQMQTQVS
DTSVVLSMDN NRSLDLDSII AEVKAQYEDI ANRSRAEAES WYQTKYEELQ VTAGRHGDDL
RNTKQEISEM NRVIQRLRAE IDSVKKQCSS LQTAIADAEQ RGELALKDAR AKLVDLEEAL
QKAKQDMARL LREYQELMNV KLALDVEIAT YRKLLEGEEC RWGQGDQRHS SSVVTSTVSS
GYGGGSNIGG GSLGLGGGSS YSFTSSTGHN LGAGPGGSSF STSSSRGLGG SGSSVKFVST
TSSSRKSYKH
//