ID A0A452SCZ8_URSAM Unreviewed; 509 AA.
AC A0A452SCZ8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030261.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030261.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452SCZ8; -.
DR Ensembl; ENSUAMT00000033754.1; ENSUAMP00000030261.1; ENSUAMG00000023210.1.
DR GeneTree; ENSGT00940000154026; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 106..399
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 197..231
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 297..377
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 509 AA; 55011 MW; 56A6D403EDC3B6E8 CRC64;
MTCGSGFCGR VFSCASACGP RPGRCCITAA PYRGVSCYRG LTGGFGSHSV CGGFRAGSCG
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KCLNSRFAAF
IDKVRFLEQQ KQCCESNLEP LFEGYIETLR REAECVEADS GRLASELNQC RSAGGYEEEV
ALRATAENEF VALKKDVDCA YVRKSDLEAN AEALTEEIDF LRRLYEEEIR VLHAHISDTS
VIVKMDNSRD LNMDCIVAEI KAQYDDIASR SRAEAESWYR SKCEEMKATV IRHGETLRRT
KEEINELNRM IQRLTAEVEN AKCQNTKLEA AVTQAEQQGE TALSDARCKL AELEAALQKA
KQDMACLVKE YQEVMNSKLG LDIEIATYRR LLEGEEQRIL TEPLGSAGVS SSRGGVVCGD
LCVSGSRPVT GSVCSAPCSG NLAVSTGMCA PCGPCAFVGT CGQDCSVSAQ VDSCWWGPGG
PQIENWTKAG VVREVPSGQG APALTSGLP
//
