ID A0A452SD02_URSAM Unreviewed; 1616 AA.
AC A0A452SD02;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=IQ motif containing GTPase activating protein 1 {ECO:0000313|Ensembl:ENSUAMP00000030210.1};
GN Name=IQGAP1 {ECO:0000313|Ensembl:ENSUAMP00000030210.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030210.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSUAMT00000033697.1; ENSUAMP00000030210.1; ENSUAMG00000021132.1.
DR GeneTree; ENSGT00950000183076; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd21274; CH_IQGAP1; 1.
DR CDD; cd05133; RasGAP_IQGAP1; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 44..159
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 663..696
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 965..1198
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 168..195
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1616 AA; 183850 MW; 181BF3AE46261C9F CRC64;
MSAADEVDGL GVARPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE
DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL
NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE
EINNMKIELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAVDR RIPADTFAAL
RNPNAMLVNL EEPLASTYQD VLYQAKQEKM TNAKNRVKME HLERDVYEEL LTQAEIQGNI
NKVNTSSALA NVDLALEQGV APALFKALQA PALGLRGLQP QNGDWYLKQL LSDRQQKRQV
KVRGEHAGTH VRPSESCAYQ RSKRLAAVAA INAAIQKGVA EKTVLELMNP EAQLPQVYPF
AADLYQKELA TLQQQSPEHN LTHPELSVAV EMLSSVALIN RALESGDMNT VWKQLSSSVT
GLTNIEEENC QRYLDELMKL KTQAHAENSA FITWNDIQAC VDQVNLVVQE EHERILAIGL
INEALDEGDA QKTLQALQIP AAKLEGVLAE VAQHYQDTLI RAKREKAQVS GSEIVPFCSE
NFIPSGVALG IYAINEAVES GDVGKTLSAL RSPDVGLYGV IPECGETYQS DLAEAKKKKL
AAGDNNSKWV KHWVKGGYYY YHNLETQEGG WEEPSDFVQN SMQLSREEIQ SSISGVTAAY
NREQLWLANE GLITKLQACC RGYLQKKAYQ DRLAYLRAHK DEVVKVWIPS PQIQSLARMH
QARKRYRDRL QYFRDHINDI IKIQAFIRAN KARDDYKTLI NAEDPPMIVV RKFVHLLDQS
DQDFQEELDL MKMREEVITL IRSNQQLEND LNLMDIKIGL LVKNKITLQD VVSHSKKLTK
KNKEQLSDMM MLNKQKGGLK ALSKEKREKL EAYQHLFYLL QTNPTYLAKL IFQMPQNKST
KFMDSVIFTL YNYASNQREE YLLLRLFKTA LQEEIKSKVD QIQEIVTGNP TVIKMVVSFN
RGARGQNALR QILAPVVKEI MDDKSLNIKT DPVDIYKSWV NQMESQTGEA SKLPYDVTPE
QALAHEEVKT RLDNSIRNMR AVTDKFLSAI ISSVDKIPYG MRFIAKVLKD SLHEKFPDAG
EDELLKIIGN LLYYRYMNPA IVAPDAFDII DLSAGGQLTT DQRRNLGSIA KMLQHAASNK
MFLGDNAHLG IINEYLSQSY QKFRRFFQTA CDVPELQDKF NVDEYSDLVT LTKPVIYISI
GEIINTHTLL LDHQDAIAPE HNDPIHELLD DLGEVPTIES LIGESAGNLN DPNKEALAKT
EVSLTLTNKF DVPGDENAEM DARTILTKRL IVDVIRFQPG ETLTEILETP ATSEQEAEHQ
RAMQRRAIRD AKTPDKMKKS KFVKEDSNLT LQEKKDKIQS GLKKLTELGT VDPKNRYQEL
INDIAKDIRN QRRYRQRRKA ELVKLQQTYA ALNSKATFYG EQVDYYKSYI KTCLDNLASK
GKVSKKPREM KGKKSKKISL KYTAARLHEK GVLLEIEDLQ VNQFKNVIFE ISPTEEVGDF
EVKAKFMGVQ METFMLHYQD LLQLQYEGVA VMKLFNRAKV NVNLLIFLLN KKFYGK
//