ID A0A452SD04_URSAM Unreviewed; 514 AA.
AC A0A452SD04;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030259.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A452SD04; -.
DR STRING; 9643.ENSUAMP00000030259; -.
DR Ensembl; ENSUAMT00000033752.1; ENSUAMP00000030259.1; ENSUAMG00000023210.1.
DR GeneTree; ENSGT00940000154026; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF52; KERATIN, TYPE II CUTICULAR HB6; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 106..403
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 201..235
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 301..381
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 514 AA; 55674 MW; 71EE1689779DB3DD CRC64;
MTCGSGFCGR VFSCASACGP RPGRCCITAA PYRGVSCYRG LTGGFGSHSV CGGFRAGSCG
RSFGYRSGGV CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKQEEKEQI KCLNSRFAAF
IDKVRFLEQQ KQCCESNLEP LFEGYIETLR REAECVEADS GRLASELNQS LSLAPFISRY
EEEVALRATA ENEFVALKKD VDCAYVRKSD LEANAEALTE EIDFLRRLYE EEIRVLHAHI
SDTSVIVKMD NSRDLNMDCI VAEIKAQYDD IASRSRAEAE SWYRSKCEEM KATVIRHGET
LRRTKEEINE LNRMIQRLTA EVENAKCQNT KLEAAVTQAE QQGETALSDA RCKLAELEAA
LQKAKQDMAC LVKEYQEVMN SKLGLDIEIA TYRRLLEGEE QRLCEGVGSV NVCVSSSRGG
VVCGDLCVSG SRPVTGSVCS APCSGNLAVS TGMCAPCGPC AFVGTCGQDC SVSAQVDSCW
WGPGGPQIEN WTKAGVVREV PSGQGAPALT SGLP
//
