ID A0A452SDI0_URSAM Unreviewed; 553 AA.
AC A0A452SDI0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Solute carrier family 22 member 12 {ECO:0000313|Ensembl:ENSUAMP00000030395.1};
GN Name=SLC22A12 {ECO:0000313|Ensembl:ENSUAMP00000030395.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030395.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A452SDI0; -.
DR STRING; 9643.ENSUAMP00000030395; -.
DR Ensembl; ENSUAMT00000033915.1; ENSUAMP00000030395.1; ENSUAMG00000023336.1.
DR GeneTree; ENSGT00940000162485; -.
DR OMA; LTWNYLQ; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0015143; F:urate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0046415; P:urate metabolic process; IEA:Ensembl.
DR CDD; cd17374; MFS_OAT; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF205; SOLUTE CARRIER FAMILY 22 MEMBER 12; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 234..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..520
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 534..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 59376 MW; 6704037DEF44766E CRC64;
MAFSELLDQV GGLGRFQVLQ VVALVVPIMW LTTQSMLENF SAAVPSHRCW VPLLDNSTAQ
ASVPGTLGPK DLLTVSIPLG PNQEPHQCLR FRQPQWQLLD PNATATNWSK AATEPCVDGW
VYDRSTFTST IVAKWDLVCD SHALKPMAQS VYLSGSLVGA AVCGHTSDRF GRRLVLTWNY
LQMAVSGTAA AFAPTFPAYC LFRFLAAFGV AGVMMNTSTL LMEWTSARAR ALAMTLNSLG
FSFGQVLMAA VAYGVRDWAL LQLAVSAPFF LCFVYSWWLA ESARWLLITG RLERGLRELR
RVAAINGKRA VEDTLTTEVL LSAMQEELSV GQAPASLGAL VCTPGLRLRT CISTLCWFAF
GFTFYGLALD LQALGSSIFL LQVLIGVVDI PAKIGSLLLL NRLGRRPTQA GSLVLSGLCI
LANMLVPYEM GALRSTLAVL GLGGLGAGFT CISVYTGELF PTVLRMTAVG LGQMATRGGA
ILGPLVRLLA VHGRSLPLLV YGGVPVLSGL AALLLPETQS LPLPDTIQDV QNQTVKKATH
STPGPTVLKS THF
//