ID A0A452SDT8_URSAM Unreviewed; 133 AA.
AC A0A452SDT8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=p53 and DNA damage-regulated protein 1 {ECO:0000256|ARBA:ARBA00016313};
GN Name=PDRG1 {ECO:0000313|Ensembl:ENSUAMP00000030576.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030576.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030576.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in chaperone-mediated protein folding.
CC {ECO:0000256|ARBA:ARBA00003581}.
CC -!- SUBUNIT: Component of the PAQosome complex which is responsible for the
CC biogenesis of several protein complexes and which consists of R2TP
CC complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members
CC PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and
CC DNAAF10/WDR92. {ECO:0000256|ARBA:ARBA00026022}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000256|ARBA:ARBA00008045}.
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DR AlphaFoldDB; A0A452SDT8; -.
DR STRING; 9643.ENSUAMP00000030576; -.
DR Ensembl; ENSUAMT00000034112.1; ENSUAMP00000030576.1; ENSUAMG00000023478.1.
DR GeneTree; ENSGT00390000013253; -.
DR OMA; FIKMPHS; -.
DR OrthoDB; 5384212at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; IEA:Ensembl.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR InterPro; IPR030482; PDRG1.
DR InterPro; IPR002777; PFD_beta-like.
DR PANTHER; PTHR21162; P53 AND DNA DAMAGE-REGULATED PROTEIN; 1.
DR PANTHER; PTHR21162:SF0; P53 AND DNA DAMAGE-REGULATED PROTEIN 1; 1.
DR Pfam; PF01920; Prefoldin_2; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT COILED 74..101
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 133 AA; 15566 MW; 1EC44474B0310A5A CRC64;
MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD LSVSEDVMVC
FGNMFIRMPH PQTKEMIEKD QDHLDKEIER LRKQLKVKVN RLFEAQGKPE LKGFNLNPLN
QDELKALKII LKG
//
