ID A0A452SEW5_URSAM Unreviewed; 1317 AA.
AC A0A452SEW5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Adhesion G protein-coupled receptor A2 {ECO:0000313|Ensembl:ENSUAMP00000030926.1};
GN Name=ADGRA2 {ECO:0000313|Ensembl:ENSUAMP00000030926.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000030926.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000030926.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR Ensembl; ENSUAMT00000034505.1; ENSUAMP00000030926.1; ENSUAMG00000023526.1.
DR GeneTree; ENSGT00940000158941; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1317
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019236694"
FT TRANSMEM 762..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 906..930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1047
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..334
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 317..411
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT REGION 557..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1073..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1166
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1317 AA; 139906 MW; A2D088EB2205D341 CRC64;
MGAAGRRMWG APARLLLQLL PWLLLLAPET RGAPGCPVPI RSCKCSGERP KGLSGGAPNP
ARRRVVCGGG DLPEPPEPGL LPNGTVTLLL SNNKITGLRN GSFLGLSLLE KLDLRNNVIS
TVQPGAFLGL GELKPLPALP HPGSLFPAPC RNISGNIFSS LQPGVFDELP ALKVLDLGTE
YLTCDCRLRW LLSWARNRSL QLSEHTLCVY PRALHAQALG GLQEAQLRCE GALELHTHHL
IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPLEG DEQAGILLAE SLIHDCTFIT
SELTLSHIGV WASGEWECSV STAQGNASKK VEIVVLETSA SYCPAERVAN NRGDFRWPRT
LAGITAYQSC LQYPFTSVPL SEGAPGTRAS RRCDRAGRWE PGDYSHCLYT NDITRVLYTF
VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM
ASNLMLVDEH LLWLAQREDK ACSGIVGALE RIGGAALSPH AQHISVNSRN VALEAYLIKP
HSYVGLTCTA FQRREAGAAG VRPGGPGQNP SPEPEPLTDQ QLRFRCTTGR PSISLSSFHI
KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN GRLFRSHGNT SRPGAAGPGK
RRGVATPVIF AGTSGCGVGN LTEPVAISLR HWAEGAEPVA AWWSQDGPGG PGGWSSEGCQ
LRSSQPNVSS LHCQHLGNVA VLMELSAFPR EVGGPGAGLH PVVYPCTAVL LLCLFSTIIT
YILSHSSIHV SRKGWHMLLN LCFHMAMTSA VFAGGITLTN YHMVCQAVGI TLHYSSLSTL
LWMGVKARVL HKELTWREPP PQEGDAAPPA PRPMLRFYLI AGGIPLIICA SLPACPRPTR
PDAGLGAFYI PVALILLITW IYFLCAGLRL RGPLAQSPKG GTSRVSLETG EELRGSTRLR
SSGPLLNDSG SLLATGSAGV VTPGPPEDGD GLYSPGVQLG ALVTTHFLYL AMWACGALAV
SQRWLPRVVC SCLYGAAASA LGLFVFTHHC ARRRDVRASW RACCPQASAS RASPRAVPAA
PEDTSPVFGE GPPSLKSSPS GSSGHAPPLG PCKLTNLQLA QSQVCEAGVV ARGEGELEPT
GSRGSLAPRH PNNLHHGRRA HKSRAKGHRA GEAGAKNRVK ALRAGAAAGA PELLSSESGS
LHNSPSDSYP GSSRNSPGLQ LEGEPMLTPS EGSDTSAAPP PDAGRPGQRH SASRDNLKGG
GAGAPERDSK RRSYPLNAAS LNGAPKGAKY DDLGGPGADA AGGACMKTGL WKSETTV
//
