ID A0A452SG32_URSAM Unreviewed; 1921 AA.
AC A0A452SG32;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin heavy chain 7B {ECO:0000313|Ensembl:ENSUAMP00000031389.1};
GN Name=MYH7B {ECO:0000313|Ensembl:ENSUAMP00000031389.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000031389.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000031389.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSUAMT00000035008.1; ENSUAMP00000031389.1; ENSUAMG00000013126.1.
DR GeneTree; ENSGT00940000160950; -.
DR OMA; CYLRQGY; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF29; MYOSIN-7B; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 25..75
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 79..770
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 647..669
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1863..1921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 834..1472
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1880..1921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1921 AA; 219030 MW; DD38AFEAC710A96B CRC64;
ATAMMDVSEL GESARYLRQG YQDLMKVKRV WVPDEQDAYV EAEIKSEATG GRVNVETKDQ
KMLMVREAEL QPMNPPRFDL LEDMAMMTHL NEASVLHNLR QRYARWMIYT YSGLFCVTIN
PYKWLPVYTA SVVAAYKGKR RSEAPPHIYA VADNAYNDML RNRENQSMLI TGESGAGKTV
NTKRVIQYFA IVAALGDGLG KKAGTLEDQI IEANPAMEAF GNAKTLRNDN SSRFGKFIRI
HFGPSGKLAS ADIDSYLLEK SRVIFQLPGE RGYHVYYQIL SGKKPELQDM LLLSMNPYDY
HFCSQGVITV DNMNDGEELM ATDHAMDILG FSVDEKCACY KIVGALLHFG NMKFKQKQRE
EQAEADGTES ADKAAYLMGV SSGDLLKGLL HPRVRVGNEY VTKGQSVEQV VFAVGALAKA
TYDRLFRWLV SRINQTLDTK LPRQFFIGVL DIAGFEIFEF NSFEQLCINF TNEKLQQFFN
QHMFVLEQEE YKREGIDWVF IDFGLDLQPC IDLIEKPLGI LSILEEECMF PKASDASFRA
KLYDNHAGKS PNFQQPRPDK KRKYQAHFEV AHYAGVVPYS VVGWLDKNKD PLNETVVPIF
QKSQNKLLAT LYENYSGSSE PPKSGVKEKR KKAASFQTVS QLHKENLNKL MTNLRATQPH
FVRCIVPNEN KTPGVMDAFL VLHQLRCNGV LEGIRICRQG FPNRLLYADF RQRYRILNPS
AIPDDTFMDS RKATEKLLGS LDIEHTQYQF GHTKVFFKAG LLGVLEELRD QRLAKVLTLL
QARSRGRLMR LEYQRLLGGR DALFTIQWNI RAFNAVKNWS WMKLFFKMKP LLRSAQAEEE
LAALRAELRG LRGALAAAEA KRQELEETHV SVTQEKNDLA LQLQAEQENL ADAEERCHLL
IKSKVQLEAK VKELSERLED EEEVNADLAA RRRKLEDECT ELKKDIDDLE LTLAKAEKEK
QATENKVKNL TEEMAALDES VARLTKEKKA LQEAHQQALG DLQAEEDRVS ALAKAKLRLE
QQVEDLECSL EQEKKLRMDT ERAKRKLEGD LKLTQESVTD TAQDKQQLEE KLKKKDSELS
QLNLRVEDEQ LLGAQLQKKI KELQARAEEL EEELEAERAA RARVEKQRAE AARELEELSE
RLEEAGGASA GQREGCRKRE AELGRLRREL EEAALRHEAT VAALRRKQAE SAAELGEQVD
SLQRVRQKLE KEKSELRMEV DDLGANVETL ARGKASAEKL CRTYEDQLSE AKIKVEELQR
QLADASTQRG RLQTESGELS RLLEEKESLI SQLSRGKASA TQSLEELRRQ LEEESKAKSA
LAHAVQALRH DCDLLREQHE EEAEAQAELQ RLLSKANAEV AQWRSKYEAD AIQRTEELEE
AKKKLALRLQ EAEEGVEAAH AKCSSLEKAK LRLQTESEDV TLELERATSA AAALDKKQRH
LERALEERRR QEEETQRELE AAQREARSLG TELFRLRHSH EEALEKHLGK EISDLTDQVS
LSGKSIQELE KAKKALEGEK SELQAALEEA EGALELEETK TLRIQLELSQ VKAEVDRKLA
EKDEECTNLR RNHQRAVESL QASLDAETRA RNEALRLKKK MEGDLNDLEL QLGHAARQGM
EAQAATRLLQ AQLKEEQAGR DEEQRLAAEL REQAQALERR AALLAAELEE LRAALEQGER
SRRLAEQELL EATERLNLLH SQNTGLLNQK KKLEVDLSQL SGEVEEAAQE RREAEEKAKK
AITDAAMMAE ELKKEQDTSA HLERMKKTLE QTVRELQARL EEAEQAALRG GKKQVQKLEA
KVRELEAELD AEQKKHAEAL KGVRKHERRV KELAYQAEED RKNLARMQDL VDKLQSKVKS
YKRQFEEAEQ QASTNLAKYR KAQHELDDAE ERADMAETQA NKLRARTRDA LGPKVHIRHL
K
//
