ID   A0A452SGM2_URSAM        Unreviewed;       542 AA.
AC   A0A452SGM2;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   Name=CHD6 {ECO:0000313|Ensembl:ENSUAMP00000031639.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000031639.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000031639.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007025}.
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DR   AlphaFoldDB; A0A452SGM2; -.
DR   Ensembl; ENSUAMT00000035281.1; ENSUAMP00000031639.1; ENSUAMG00000024036.1.
DR   GeneTree; ENSGT00940000158986; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR   PANTHER; PTHR46850:SF3; DNA HELICASE; 1.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50013; CHROMO_2; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          41..84
FT                   /note="Chromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50013"
FT   DOMAIN          139..313
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
SQ   SEQUENCE   542 AA;  63156 MW;  72E015FDE940649A CRC64;
     MEELEKDPRI AQKIKRFRNK QAQMKHIFTE PDEDLFNPDY VEVDRVLEVA HTKDAETGEE
     VTHYLVKWCS LPYEESTWEL EEDVDPAKVK EFESLQVLPE IKHVERPASD SWQKLEKSRE
     YKNSNQLREY QLEGMNWLLF NWYNRKNCIL ADEMGLGKTI QSITFLSEIF LRGIHGPFLI
     IAPLSTITNW EREFRTWTEM NAIVYHGSQI SRQMIQQYEM VYRDAQGNPL SGVFKFHVVI
     TTFEMILADC PELKKIHWSC VIIDEAHRLK NRNCKLLEGL KLMALEHKVL LTGTPLQNSV
     EELFSLLNFL EPSQFPSETA FLEEFGDLKT EEQVKKLQSI LKPMMLRRLK DDVEKNLAPK
     QETIIEVELT NIQKKYYRAI LEKNFSFLTK GANQHNMPNL INTMMELRKC CNHPYLINGA
     EEKILEDFRK THSPDAPDFQ LQAMIQAAGK LVLIDKLLPK LIAGGHKVLI FSQMVRCLDI
     LEDYLIQRRY TYEQPSTGSV SQTQTALSFF CAPEREAWAS ISQPPIPASY LIQTGTHKMT
     CR
//