ID A0A452SGR7_URSAM Unreviewed; 1480 AA.
AC A0A452SGR7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Condensin-2 complex subunit D3 {ECO:0000256|PIRNR:PIRNR036508};
GN Name=NCAPD3 {ECO:0000313|Ensembl:ENSUAMP00000031742.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000031742.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000031742.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the condensin-2 complex, a complex
CC which establishes mitotic chromosome architecture and is involved in
CC physical rigidity of the chromatid axis.
CC {ECO:0000256|PIRNR:PIRNR036508}.
CC -!- SUBUNIT: Component of the condensin-2 complex.
CC {ECO:0000256|PIRNR:PIRNR036508}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036508}.
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DR Ensembl; ENSUAMT00000035400.1; ENSUAMP00000031742.1; ENSUAMG00000024192.1.
DR GeneTree; ENSGT00940000153566; -.
DR OMA; RIHPNIC; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IEA:UniProtKB-UniRule.
DR GO; GO:0000796; C:condensin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026971; CND1/NCAPD3.
DR InterPro; IPR032682; Cnd1_C.
DR InterPro; IPR012371; NCAPD3.
DR PANTHER; PTHR14222; CONDENSIN; 1.
DR PANTHER; PTHR14222:SF1; CONDENSIN-2 COMPLEX SUBUNIT D3; 1.
DR Pfam; PF12717; Cnd1; 1.
DR PIRSF; PIRSF036508; Condns_HCP-6; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|PIRNR:PIRNR036508};
KW Cell division {ECO:0000256|PIRNR:PIRNR036508};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067,
KW ECO:0000256|PIRNR:PIRNR036508}; Mitosis {ECO:0000256|PIRNR:PIRNR036508};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036508};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 950..1117
FT /note="Condensin complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12717"
FT REGION 148..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1437..1480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1242..1269
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 148..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1480 AA; 166787 MW; 2F9B48CDCB400727 CRC64;
MVALPGLGSG LQPWCPLDLS TEWVDTVWEL DFTETEPLDP SIEAEILDTG LNAFTKLYES
IFPKKKSIWT FFIENSISHR ALVALFYHFV QTVHKKSASV QYRQYGLHAA GLYFLLLEVP
GSVANQVFHQ VMFDKCIQIL KKSWPQESKL NRKRKKEQPK NSEVNPRGNR KRGKPPRKED
IEVDEIEEQE DEENICFSAR DLCQIRNAIF HLLKNFLRLL SKFSLKEKPQ CIQNCIEVFV
ALTNFEPILH EFHVTQARNL NQAKYVPELA YHGLYLLCSP IHGEGDTVIG CVFHQMLNVI
LMLEAGKGAH HAPLSITTSV INGRNQAVQF ISSLVDELKE DVFPVLRILL QHICAKVTDK
SEYRTYAAQS LVQLLSKLPS REYATFIAWL YRYSRSSKIP HRVFTLDVVL ALLELPERAV
DNTLSLEHQK ILKHKFLVQE ILFDRCVDKA PTVRSKALSS FAHCLEVSVT TASESIVELL
INSPAISRIE SHPGTLLRNS SAFSCQRQTL NPTGGSGVIN IDSSGETDGS GVRCVMAMLK
KRIRDEKTNV RKSALQVLVS ILKHCNISGM KEELSLLQDQ CRDPAVSVRK QALQSLTELL
MAQPECVQMQ KAWLTGIIPA VMDCESTVQE KALECLDQLL LQNIKHYNKF HNGDNSQVLA
WALLTLLSTE NQELSRYLNK AFHIWSKKEK FSSSFINNVI SYTDTELSAP AWMLLSKIAC
SSPRLDYTKI IESWEKISSQ QNPNSNTLGH ILCVIGRIAK HLPKSTRDKV TDVVKCKLNG
FQWSLELISS AVDTLQRLCR ASAETPVEEQ ELLKQVCGDV LSTCVQSLSE IVLKQSGPGN
MDEDLFVKYI FTLGDIAQLC PARVEKRAFL LIQSIVASSV DADHPTSSQG SSEAPVFQPL
SQVRGCVMPS VIRAHAIITL GKLCLQHEDL AKKSIPALVR ELEVCDDVAV RNNVVIVMCD
LCIRYTVMVD KYIPNISVCL KDSHPFIRKQ TLILLTNLLQ EEFVKWKGSL FFRFVSTLID
SHPDIASFGE FCLAHLLLKR NPVMFFQHFI ECIFHFNNYE KHEKYNKFPQ SERSKRLFSL
KGKTNKQKRM KIYKFLLEHF TDEQRFNITS KICLSILASF ADGILPLDME ASELLSDTFE
VLSSKEIKLL AMRAKADKDL LMEEDDTALA SAVMQEAQKR LISQVQKKNF IENIIPIIIS
LKTVLEKNKI PALRELMTYL REVMQDYRDE IKDFFALDKQ LASELEYDIK KYNEQLAQEQ
ELARQADVSG VAYRARGTQT AQVAPSLEVM PALAGQEGAT VPAAASQPST PRAVAGQAPP
LSPSLETGLL KRFMPKGRPM SLSTIAILNS VKKAVESNSR HRRRSTGGLP LALSSQSLDR
MCHRGKSQVP GSSRGRWQSW TINDVTFGAE VSYIGTPRTP SSVKEKTEAQ CPGNDILCLS
LPDKPPPQPQ QWNVKSPARN KDNPAPTRRS LRKTPLKTAN
//
