ID A0A452SGW1_URSAM Unreviewed; 978 AA.
AC A0A452SGW1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|Ensembl:ENSUAMP00000031707.1};
GN Name=RAPGEF4 {ECO:0000313|Ensembl:ENSUAMP00000031707.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000031707.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000031707.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452SGW1; -.
DR Ensembl; ENSUAMT00000035362.1; ENSUAMP00000031707.1; ENSUAMG00000024101.1.
DR GeneTree; ENSGT00940000156075; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 44..147
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 201..276
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 341..442
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 481..619
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 757..976
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 978 AA; 111451 MW; 9FDB5C943B0B5893 CRC64;
MALNSLISEV THATFCAFSP FYRPLERSSE DVDIIFTRLK EVKAFEKFHP NLLHQICLCG
YYENLEKGIT LFRQGDIGTN WYAVLAGSLD VKVSETSSHQ DAVTICTLGI GTAFGESILD
NTPRHATIVT RESSELLRIE QKDFKALWEK YRQYMAGLLA PPYGTPLIEP HVPLRPANTI
SKVPSEKILR AGKILRNAIL SRAPHMIRDR KYHLKTYRQC CVGTELVDWM LQQTSCVHSR
TQAVGMWQVL VEDSVLNHVD QEHHFQDKYL FYRFLDDEHE DAPLPTEEEK KECDEELQDT
MLLLSQMGPD AHMRMILRKP PGQRTVDDLE IIYEELIHIK ALSHLSTTVK RELAGVLIFE
SHAKGGTVLF NQGEEGTSWY IILKGSVNVV IYGKGVVCTL HEGDDFGKLA LVNDAPRAAS
IVLREDNCHF LRVDKEDFNR ILRDVEANTV RLKEHDQDVL VLEKVPAGNR ASNQGNSQPQ
QKYTVMSGTP EKILEHFLET IRLEPALNEA TDSVLNDFVM MHCVFMPNTQ LCPALVAQYP
FVPSQGTEQE KMDYALNSKR RVIRLVLQWA AVYGDVLQED DVAVAFLEEF YVSVSDDARM
IAALKDQLPE LEKIVKQISE DAKAPQKKHK VLLQQFNTGD ERAQKRQPIR GSDEVLFKVY
CMDHTYTTIR VPVAASVKEV ISAVADKLGS GESLIIVKMS SGGEKVVLKP NDVSVFTTLT
INGRLFACPR EQFDSLTPLP EQEGPTVGTV GTFELMSSKD LAYQMTIYDW ELFNCVHELE
LIYHTFGRHN FKKTTANLDL FLRRFNEIQF WVVTEICLCS QPSKRVQLLK KFIKIAAHCK
EYKNLNSFFA IVMGLSNVAV SRLALTWEKL PSKFKKFYAE FESLMDPSRN HRAYRLTVAK
LEPPLIPFMP LLIKENKAVS YMHILRDANL LFSPSTDPDA AQANKNHQDV RSYVRQLNVI
DNQRTLSQMS HRLEPRRP
//