ID   A0A452SGZ0_URSAM        Unreviewed;       663 AA.
AC   A0A452SGZ0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Histidine decarboxylase {ECO:0000256|ARBA:ARBA00039946};
DE            EC=4.1.1.22 {ECO:0000256|ARBA:ARBA00012320};
GN   Name=HDC {ECO:0000313|Ensembl:ENSUAMP00000031820.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000031820.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000031820.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00009533}.
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DR   AlphaFoldDB; A0A452SGZ0; -.
DR   STRING; 9643.ENSUAMP00000031820; -.
DR   Ensembl; ENSUAMT00000035481.1; ENSUAMP00000031820.1; ENSUAMG00000024354.1.
DR   GeneTree; ENSGT00940000157938; -.
DR   OMA; MKREDSC; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0004398; F:histidine decarboxylase activity; IEA:Ensembl.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0042423; P:catecholamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0001694; P:histamine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006548; P:histidine catabolic process; IEA:Ensembl.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 1.20.1340.10; dopa decarboxylase, N-terminal domain; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010977; Aromatic_deC.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   PANTHER; PTHR11999; GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR11999:SF68; HISTIDINE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   PRINTS; PR00800; YHDCRBOXLASE.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   3: Inferred from homology;
KW   Catecholamine biosynthesis {ECO:0000256|ARBA:ARBA00022584};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   MOD_RES         305
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   663 AA;  74180 MW;  F6266AE150A25A5B CRC64;
     VMEPEEYRER GKEMVDYICQ YLSTVRERRV TPDVRPGYLR AQLPESAPEE PDSWDSIFGD
     IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN CLGFTWASSP VCTELEMHVM
     DWLAKMLGLP EHFLHHHPGS QGGGVLQSTV SESTLIALLA ARKDKILEMK ASEPGADESS
     LNARLIAYAS DQAHSSVEKA GLISLVKMKF LPVDDNFSLR GEALQKAIKE DKERGLVPVF
     VCATLGTTGV CAFDCLSELG PICASEGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
     FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GKATDFMHWQ IPLSRRFRSI
     KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPFFEI PAKRHLGLVV FRLKGPNCLT
     ESVLKELAKA GHLFLIPATI QDKLIIRFTV TSQFTTREDI LRDWNLIRDA ATLILSQHCT
     SQPSPQVGNL IPPTTGPRAL ANGMSLQSAN GAGYDPAQTR KIIKQPQPVG ASPMKREDSC
     HLENLLDPLD DDCFSEEAPD VTKHKLSSFL FNYLSVQNKK KAVRSFSCNS MPVSAQKPLP
     TDGSVKNGGS SRARIFSRFP EEMMMLKKSA FKKLIKFYSV PSFPECSSQC GLQLPCCPLQ
     AMV
//