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Database: UniProt
Entry: A0A452SIX3_URSAM
LinkDB: A0A452SIX3_URSAM
Original site: A0A452SIX3_URSAM 
ID   A0A452SIX3_URSAM        Unreviewed;       957 AA.
AC   A0A452SIX3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   Name=IGHMBP2 {ECO:0000313|Ensembl:ENSUAMP00000032502.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000032502.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000032502.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00000600};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC         Evidence={ECO:0000256|ARBA:ARBA00000600};
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
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DR   AlphaFoldDB; A0A452SIX3; -.
DR   Ensembl; ENSUAMT00000036223.1; ENSUAMP00000032502.1; ENSUAMG00000024817.1.
DR   GeneTree; ENSGT00930000151035; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd18044; DEXXQc_SMUBP2; 1.
DR   CDD; cd02641; R3H_Smubp-2_like; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 2.40.30.270; -; 1.
DR   Gene3D; 4.10.1110.10; AN1-like Zinc finger; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035896; AN1-like_Znf.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR034072; R3H_Smubp-2.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR004483; SMUBP-2/Hcs1-like.
DR   InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR   InterPro; IPR000058; Znf_AN1.
DR   NCBIfam; TIGR00376; IGHMBP2 family helicase; 1.
DR   PANTHER; PTHR43788:SF8; DNA-BINDING PROTEIN SMUBP-2; 1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF01424; R3H; 1.
DR   Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR   Pfam; PF01428; zf-AN1; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00393; R3H; 1.
DR   SMART; SM00154; ZnF_AN1; 1.
DR   SUPFAM; SSF118310; AN1-like Zinc finger; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF82708; R3H domain; 1.
DR   PROSITE; PS51061; R3H; 1.
DR   PROSITE; PS51039; ZF_AN1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00449}.
FT   DOMAIN          681..744
FT                   /note="R3H"
FT                   /evidence="ECO:0000259|PROSITE:PS51061"
FT   DOMAIN          857..906
FT                   /note="AN1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51039"
FT   REGION          606..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          798..839
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          920..957
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..759
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        824..839
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        925..957
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  104185 MW;  E3EB6C0CBFCA159C CRC64;
     MATAAVESFV TKQLDLLELE RDAEVEERRS WQESISPKEL QSRGVCLLKL QVSSQRTGLY
     GRLLVTFEPR RCASAPVLPS NSFTSGDIVG LYDEGSQLAT GILTRITQRS VTVAFDESHD
     FQLSLDREQS YRLLKLANDV TYKRLKKALI TLKKYHSGPA SSLIEVLFGG SAPSPASEIQ
     PPLFCNASLD ASQKEAVSFA LSQKELAIIH GPPGTGKTTT VVEIILQAVR QGLKVLCCAP
     SNIAVDNLVE RLARCKQRVL RLGHPARLLE SIQQHSLDAV LARSDNAQIV ADIRKDIDQA
     FAKNRQTQDK REKSSVWSEI KLLRKELKER EEAAMLESLT SAAVVLATNT GASSDGPLKL
     LPDSHFDVAV IDECAQALEA SCWIPLLKAR KCILAGDHKQ LPPTTVSHNL MERLAEEHGV
     RVVRTLTWAS DALYHGQLTA HPSVAGHLLR DLPGVAATEE TGIPLLLVDT AGCGLFELEE
     EDDQSKGNPG EVRLVSLHIQ ALVDAGVQAS DIAVITPYNL QVDLLRQSLA HRHPELEIKS
     VDGFQGREKE AVVLSFVRSN RKGEVGFLAE DRRINVAVTR TLVDHFTEHG EVRTAFEYLD
     DIIPENYSHE SSQGHGQTGA KPHGSAALAR KPPGGRPQEG AQGARAAAGL EQKRPGGKPS
     GPEVPSQPTL NGGSPEGAGS RDRAERFRAK IAEFVASEKT QLEFPASLNS HDRMWIHQIA
     EEHGLRHDST GEGKKRFITV SKRAPPAPPA PPPPAGAGSQ TPVGPRAPGP TQTDPPLGEP
     SSQDPLNLKA LHLERLQREK SRQERPAKEG PAKEGQQASR SGLRTLPEKK KKKEAKGHAA
     VDLPSEEDFD ALVAAAIKAD NSCGLAKCTA SVVTLGQLCL HCGLRFCLSH HLPEIHGCGE
     RARAHARQRI SREGVLYAGS GTKDRSLDPA KRAQLQRRLD KKLDELTSQR KSKRKEK
//
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