ID   A0A452SIX6_URSAM        Unreviewed;      1159 AA.
AC   A0A452SIX6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=TSC complex subunit 1 {ECO:0000313|Ensembl:ENSUAMP00000032459.1};
GN   Name=TSC1 {ECO:0000313|Ensembl:ENSUAMP00000032459.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000032459.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000032459.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452SIX6; -.
DR   Ensembl; ENSUAMT00000036179.1; ENSUAMP00000032459.1; ENSUAMG00000024563.1.
DR   GeneTree; ENSGT00390000014148; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007483; Hamartin.
DR   PANTHER; PTHR15154; HAMARTIN; 1.
DR   PANTHER; PTHR15154:SF2; HAMARTIN; 1.
DR   Pfam; PF04388; Hamartin; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   REGION          489..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          989..1048
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1113..1159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          721..815
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        518..532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1159 AA;  127967 MW;  AB23E1609ED4D2E8 CRC64;
     MAQQANLGEL LSMLDSPVLS VRDEVTAVFK ENLSSDRGPM LVNTLVDYYL ETKSQPVLHI
     LTTLQEPHDK HLLDKMNDCM GRAASRLPAL SLLGHVIRLQ PPWKHKLSQA PLLPSLLKCL
     KVDTDVIVLT TGVLVLITML PMIPQSGKQH LHDFFDIFGR LSSWCLKKPG HVTEIYLVHL
     HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENLDTFEEVV RPMMEHVRIH PELVTGSKDH
     ELDPRRWKRL ETHDVVIECA KISLDPAEAS YEDGDSVSPQ VSARFPHRAA DVAASPYVDM
     QNSCGSATST PYSSSRLTLF STPGQPPQTL SPPSTRLLTE PPQATLWSPS MVCGMTTPPT
     SPGNVPPDLS HPYSKVFGTT AGGKGTPLGT PATSPPPAPL CHSDDYVHIS LRQATATPPK
     KVCAGVSALP LPHCLCFSLE ELPGSKGSVP LSDLPGFLGD LASEEDSIEK AKEEAAISKE
     LSEITTAGTE PLVPRGGFDS PFYRDSLPGC PRKNHSAASG AQGASVNPEP LNSSLDKLGP
     DTPKQAFTPI DPPCGGANQS PAGSRERQTA LETDILTPSP CKIPPQRGVG FGSGQPPPYD
     HLFEVALPKT AHHFVSKKTK ELLKKAKGNA EEDCPPSTSP AEVLDRLIQQ GADAHSKELN
     KLSLPSKSVD WTHFGGSPPS DEIRTLRNQL LLLHNQLLYE RFKRQQHALR NRRLLRRVIR
     AAALEEHNAA MKDQLKLQEK DIQIWKVSMQ KEQARYSQLQ EQRDTMVTQL HSQIRQLQHD
     REEFYNQSQE LQTKLEDCRN MIAELRLELK KANSKVCHTE LLLSQVSQKL SNSESVQQQM
     EFLNRQLLVL GEVNELYLEQ LQSKHSDTTK EVEMMKAACR KELEKNRSHV LQQNQRLDTS
     QKRILELESH LAKKDHLLLE QKKYLEDVKV QARGQLQAAE SRYEAQKRIT QVFELEILDL
     YGRLEKDGLL KKLEEEKAEA AEAAEERLAS CKDGCSDSVT GHNEEASGHN GETKPPRPGG
     GARGGGASRG GGGGSELSTP EKPPTQRAGL FSSRWETTVG ESATSIPTTV GSFPSSKSFL
     GMKARELFRN KSESQCDEDS VTISSLSETL KTELGKDPGA EAKTPLHLDG PQPSPPSPDS
     VGQLHIMDYD ETHQEHSEG
//