ID   A0A452SIZ1_URSAM        Unreviewed;       991 AA.
AC   A0A452SIZ1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=TSC complex subunit 1 {ECO:0000313|Ensembl:ENSUAMP00000032450.1};
GN   Name=TSC1 {ECO:0000313|Ensembl:ENSUAMP00000032450.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000032450.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000032450.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452SIZ1; -.
DR   Ensembl; ENSUAMT00000036168.1; ENSUAMP00000032450.1; ENSUAMG00000024563.1.
DR   GeneTree; ENSGT00390000014148; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007483; Hamartin.
DR   PANTHER; PTHR15154; HAMARTIN; 1.
DR   PANTHER; PTHR15154:SF2; HAMARTIN; 1.
DR   Pfam; PF04388; Hamartin; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   REGION          413..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          510..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          725..819
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        416..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..536
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   991 AA;  110973 MW;  9D501986AC524632 CRC64;
     MAQQANLGEL LSMLDSPVLS VRDEVTAVFK ENLSSDRGPM LVNTLVDYYL ETKSQPVLHI
     LTTLQEPHDK HLLDKMNDCM GRAASRLPAL SLLGHVIRLQ PPWKHKLSQA PLLPSLLKCL
     KVDTDVIVLT TGVLVLITML PMIPQSGKQH LHDFFDIFGR LSSWCLKKPG HVTEIYLVHL
     HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENLDTFEEVV RPMMEHVRIH PELVTGSKDH
     ELDPRRWKRL ETHDVVIECA KISLDPAEAS YEDGDSVSPQ VSARFPHRAA DVAASPYVDM
     QNSCGSATST PYSSSRLTLF STPGQPPQTL SPPSTRLLTE PPQATLWSPS MVCGMTTPPT
     SPGNVPPDLS HPYSKVFGTT GGKGTPLGTP ATSPPPAPLC HSDDYVHISL RQATATPPKK
     EEKTDSARPC LHRQHHLPND RGLEELPGSK GSVPLSDLPG FLGDLASEED SIEKAKEEAA
     ISKELSEITT AGTEPLVPRG GFDSPFYRDS LPGCPRKNHS AASGAQGASV NPEPLNSSLD
     KLGPDTPKQA FTPIDPPCGG ANQSPAGSRE RQTALETDIL TPSPCKIPPQ RGVGFGSGQP
     PPYDHLFEVA LPKTAHHFVS KKTKELLKKA KGNAEEDCPP STSPAEVLDR LIQQGADAHS
     KELNKLSLPS KSVDWTHFGG SPPSDEIRTL RNQLLLLHNQ LLYERFKRQQ HALRNRRLLR
     RVIRAAALEE HNAAMKDQLK LQEKDIQIWK VSMQKEQARY SQLQEQRDTM VTQLHSQIRQ
     LQHDREEFYN QSQELQTKLE DCRNMIAELR LELKKANSKV CHTELLLSQV SQKLSNSESV
     QQQMEFLNRQ LLVLGEVNEL YLEQLQSKHS DTTKEVEMMK AACRKELEKN RSHVLQQNQR
     LDTSQKRILE LESHLAKKDH LLLEQKKYLE DVKVQARGQL QAAESRYEAQ KRITQVFELE
     ILDLYGRLEK DGLLKKLEEE KAEAAEAAEE R
//