ID A0A452SKK8_URSAM Unreviewed; 1323 AA.
AC A0A452SKK8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|Ensembl:ENSUAMP00000033107.1};
GN Name=DOCK4 {ECO:0000313|Ensembl:ENSUAMP00000033107.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000033107.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000033107.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00984}.
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DR Ensembl; ENSUAMT00000036889.1; ENSUAMP00000033107.1; ENSUAMG00000024071.1.
DR GeneTree; ENSGT00940000155659; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11705; DHR2_DOCK4; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR InterPro; IPR037014; DHR2_DOCK4.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF7; DEDICATOR OF CYTOKINESIS PROTEIN 4; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 601..1007
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1060..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 877..904
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1060..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1323 AA; 151906 MW; F48D2C9155DCA022 CRC64;
MLDLLKWRTH PDKITGCLSK IKEIDGSEIV KFLQDTLDTL FGILDENSQK YGSKVFDSLV
HIINLLQDSK FHHFKPVMDT YIESHFAGAL AYRDLIKVLK WYVDRITEAE RQEHIQEVLK
AQEYIFKYIV QSRRLFSLAT GGQNEEEFRC CIQELLMSVR FFLSQESKGS GALSQSQAVF
LSSFPAVYSE LLKLFDVREV ANLVQDTLGS LPTIVHVDDS LQAVKLQCIG KTVESQLYTN
PDSRYILLPV VLHHLHMHLQ EQKDLIMCAR ILSNVFCLIK KNSSEIDVIV ASLLDILLRT
ILEITSRPQP SGSAMRLQFQ DVTGEFVACL LSLLRQMTDR HYQQLLDSFN TKEELRDFLL
QIFTVFRILI RPEMFPKDWT VMRLVANNVI ITTVLYLSDA LRKNFLNENF DYKIWDSYFY
LAVIFINQLC LQLEMFTPSK KKKVLEKYGD MRVTMGCEIF SMWQNLGEHK LHFIPALIGP
FLEVTLIPQP DLRNVMIPIF HDMMDWEQRR SGNFKQVEAK LIDKLDSLMS EGKGDETYRE
LFNSILLKKI ERETWRESGV SLIATVTRLM ERLLDYRDCM KMGEVDGKKI GCTVSLLNFY
KTELNKEEMY IRYIHKLYDL HLKAQNFTEA AYTLLLYDEL LEWSDRPLRE FLTYPMQTEW
QRKEHLHLAI IQNFDRGKCW ENGIILCRKI AEQYESYYDY RNLSKMRMME ASLYDKIMDQ
QRLEPEFFRV GFYGKKFPFF LRNKEFVCRG HDYERLEAFQ QRMLNEFPHA IAMQHANQPD
ETIFQAEAQY LQIYAVTPIP ESQEVLQREG VPDNIKSFYK VNHIWKFRYD RPFHKGTKDK
ENEFKSLWVE RTSLYLVQSL PGISRWFEVE KREVVEMSPL ENAIEVLENK NQQLKTLISQ
CQTRQMQNIN PLTMCLNGVI DAAVNGGVSR YQEAFFVKEY ILSHPEDGEK IARLRELMLE
QAQILEFGLA VHEKFVPQDM RPLHKKLVDQ FFVMKSSLGI QEFSACIQAS PVHFPNGSPR
VCRNSAPASM SPDGTRVIPR RSPLSYPAVN RYSSSSLSSQ ASAEVSNITG QSESSDEVFN
MQPSPSTSSL SSTHSASPNV TSSAPSSARA SPLLSDKHKH SRENSCLSPR ERPCSAIYPT
AVEPSQRLLF NHIGEGALPR SDPNLSAPEK GGYQASLFIS PQGSVQSFTP SPVEYHSPGL
ISNSPVLSGS YSSGISSLSR CSTSETSGFE NQVNEQSAPG PSYSGPEEPG RKESKTPPPY
SVYERTLRRP VPLPHSLSIP VTAEPPALPP KPLAARPGHL ENGTRRTEPG PRPRPLPRKV
SQL
//