ID A0A452SKR6_URSAM Unreviewed; 544 AA.
AC A0A452SKR6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|Ensembl:ENSUAMP00000033217.1};
GN Name=SOCS7 {ECO:0000313|Ensembl:ENSUAMP00000033217.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000033217.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000033217.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A452SKR6; -.
DR STRING; 9643.ENSUAMP00000033217; -.
DR Ensembl; ENSUAMT00000037014.1; ENSUAMP00000033217.1; ENSUAMG00000025322.1.
DR GeneTree; ENSGT00940000156314; -.
DR OMA; RGSCSTH; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10388; SH2_SOCS7; 1.
DR CDD; cd03741; SOCS_SOCS7; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035866; SOCS7_SH2.
DR InterPro; IPR037346; SOCS7_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF37; SUPPRESSOR OF CYTOKINE SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 363..472
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 467..517
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..103
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..198
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 58956 MW; 293CC41AF8F07A0F CRC64;
MVFRNVGRPP EEEDAEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL
AALGLGQPAG PGVKTVGGGC CPCPCPCPPQ PPPPQPQPPA AAPQAGEDPT ETSDALLVLE
GLESEAESLE TNSCSEEELS SPGRGGGGGG RLLLQPPGPE LPPVPFPMQD LVPPGRLGRG
EPQQPPPPPP PPGPLRPLAG PSRKGSLKIR LSRLFRTKSC NGGSGGGDGA GKRPSGDLAA
SAASLTDVGG SAGRELDAGR KPRLTRTQSA FSPVSFSPLF TGETVSLVDV DISQRGLTSP
HPPTPPPPPR RSLSLLDAFP RIAPIRAAES LHSQPPQHLQ CPLYRPDSSS FAASLRELEK
CGWYWGPMNW EDAEMKLKGK PDGSFLVRDS SDPRYILSLS FRSQGITHHT RMEHYRGTFS
LWCHPKFEDR CQSVVEFIKR AIMHSKNGKF LYFLRSRVPG LPPTPVQLLY PVSRFSNVKS
LQHLCRFRIR QLVRIDHIPD LPLPKPLISY IRKFYYYDPQ EEVYLSLKEA QLISKQKQEV
EPST
//
