ID A0A452SL89_URSAM Unreviewed; 1416 AA.
AC A0A452SL89;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 {ECO:0000313|Ensembl:ENSUAMP00000033405.1};
GN Name=SMARCA2 {ECO:0000313|Ensembl:ENSUAMP00000033405.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000033405.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000033405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR Ensembl; ENSUAMT00000037213.1; ENSUAMP00000033405.1; ENSUAMG00000024701.1.
DR GeneTree; ENSGT00940000154821; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18063; DEXHc_SMARCA2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.40.5.120; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR014978; Gln-Leu-Gln_QLQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029295; SnAC.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR10799:SF541; GLOBAL TRANSCRIPTION ACTIVATOR SNF2L2-RELATED; 1.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR Pfam; PF07533; BRK; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF08880; QLQ; 1.
DR Pfam; PF14619; SnAC; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00951; QLQ; 1.
DR SMART; SM01314; SnAC; 1.
DR SUPFAM; SSF160481; BRK domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS51666; QLQ; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 171..206
FT /note="QLQ"
FT /evidence="ECO:0000259|PROSITE:PS51666"
FT DOMAIN 425..497
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 755..920
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1067..1229
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..32
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1416 AA; 160987 MW; D56A34C54092C8BD CRC64;
MSTPTDPGAM PHPGPSPGPG PSPGPILGPR PGPSPGSVHS MMGPSPGPPS VSHPMPTMGS
ADFPQESTHQ MHKPIDGLHD KGIVEDMHCG SMKGSGMRPP HPGMGPPQSP MDQHSQGYMS
PHPSPLGAPE HVSSPMSGGG PTPPQMPPSQ PGPLISGDPQ AMSQPSRGPS PFSPVQLHQL
RAQILAYKML ARGQPLPETL QLAVQGKRTL PGMQQPQDAW FCLLTFSSFP LPALPPSSSP
FLPSSSLVWR WSVVPVAGAV GRPGGGCRAP ACPSCPCRSC PAGPGPELSG PSTPQKLPPA
PGQPSPILQL QQKQSRISPI QKPQGLDPVE ILQEREYRLQ ARIAHRIQEL ENLPGSLPPD
LRTKATVELK ALRLLNFQRQ LRQEVVACMR RDTTLETALN SKAYKRSKRQ TLREARMTEK
LEKQQKIEQE RKRRQKHQEY LNSILQHAKD FKEYHRSVAG KIQKLSKAVA TWHANTEREQ
KKETERIEKE RMRRLMAIHG SLPWCCYFLM GVDKYRRNWF TSLAWVSGFI GHSFLEWDLR
AEDEEGYRKL IDQKKDRRLA YLLQQTDEYV ANLTNLVWEH KQAQAAKEKK KRRRRKKAEE
IAEGGESALG PDGEPIDESS QMSDLPVKVT HTETGKVLFG PEAPKASQLD AWLEMNPGYE
VAPRSDSEES DSDYEEEVCG HLCWCGVRGK PLCLAVTTTA KQDVDDEYSM QYSARGSQSY
YTVAHAISER VEKQSALLIN GTLKHYQLQG LEWMVSLYNN NLNGILADEM GLGKTIQTIA
LITYLMEHKR LNGPYLIIVP LSTLSNWTYE FDKWAPSVVK ISYKGTPAMR RSLVPQLRSG
KFNVLLTTYE YIIKDKHILA KIRWKYMIVD EGHRMKNHHC KLTQVLNTHY VAPRRILLTG
TPLQNKLPEL WALLNFLLPT IFKSCSTFEQ WFNAPFAMTG ERVDLNEEET ILIIRRLHKV
LRPFLLRRLK KEVESQLPEK VEYVIKCDMS ALQKILYRHM QAKGILLTDG SEKDKKGKGG
AKTLMNTIMQ LRKICNHPYM FQHIEESFAE HLGYSNGLYR ASGKFELLDR ILPKLRATNH
RVLLFCQMTS LMTIMEDYFA FRNFLYLRLD GTTKSEDRAA LLKKFNEPGS QYFIFLLSTR
AGGLGLNLQA ADTVVIFDSD WNPHQDLQAQ DRAHRIGQQN EVRVLRLCTV NSVEEKILAA
AKYKLNVDQK VIQAGMFDQK SSSHERRAFL QAILEHEEEN EEEDEVPDDE TLNQMIARRE
EEFDLFMRMD MDRRREDARN PKRKPRLMEE DELPSWIIKD DAEVERLTCE EEEEKIFGRG
SRQRRDVDYS DALTEKQWLR VGVAIEDGNL EEMEEEVRLK KRKRRRNVDK DPAKEDVEKA
KKRRGRPPAE KLSPNPPKLT KQMNAIIDTV INYKDR
//
