ID A0A452SLH9_URSAM Unreviewed; 1566 AA.
AC A0A452SLH9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Myosin-4 {ECO:0000256|ARBA:ARBA00044107};
DE AltName: Full=Myosin heavy chain 2b {ECO:0000256|ARBA:ARBA00044300};
DE AltName: Full=Myosin heavy chain 4 {ECO:0000256|ARBA:ARBA00044226};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000033474.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000033474.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSUAMT00000037284.1; ENSUAMP00000033474.1; ENSUAMG00000025308.1.
DR GeneTree; ENSGT00940000163646; -.
DR OMA; PGEVNQP; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 2.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF78; MYOSIN-4; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..754
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 631..653
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1097..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1566 AA; 179542 MW; 99EEBA6EFE247D9D CRC64;
MSSDTEMAIF GEAAPYLRKS EKERIEAQNR PFDAKNSVFV VDAKESYVKS TVQSREGGKV
TVKTDAGATV TVKEDQVFSM NPPKYDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA ITGEKKKEEP TPGKMQGTLE DQIISANPLL EAFGNAKTVR
NDNSSRFGKF IRIHFGATGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPEL
IEMLLITTNP YDFAFVSQGE ITVPSIDDQE ELLATDSAVD ILGFSTDEKA AIYKLTGAVM
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK ALCYPRVKVG NEYVTKGQTV
QQVYNAVGAL AKAIYEKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC
INFTNEKLQQ FFNHHMFLIE KPMGIFSILE EECMFPKATD TSFKNKLYEQ HLGKSANFQK
PKPAKGKAEA HFSLVHYAGT VDYNIAGWLD KNKDPLNETV VGLYQKSGMK TLALLFAGGQ
SAEAESGGGK KGAKKKGSSF QTVSALFREN LNKLMTNLRS THPHFVRCII PNETKTPGAM
EHELVLHQLR CNGVLEGIRI CRKGFPSRIL YADFKQRYKV LNASAIPEGQ FIDSKKASEK
LLGSIDIDHN QYKFGHTKVF FKAGLLGTLE EMRDEKLAQL ITRTQAVCRG YLMRVEFKKM
MERRESIFCI QYNVRAFMNV KHWPWMKLYF KIKPLLKSAE TEKEMATMKE EFEKTKEELA
KSEAKRKELE EKMVALMQEK NDLQLQVQSE ADGLADAEER CDQLIKTKIQ LEAKIKELTE
RAEEEEEINA ELTAKKRKLE DECSELKKDI DDLELTLAKV EKEKHATENK VKNLTEEMAG
LDETIAKLTK EKKALQEAHQ QTLDDLQAEE DKVNTLTKAK TKLEQQVDDL EGSLEQEKKI
RMDLERAKRK LEGDLKLAQE STMDVENDKQ QLDEKFKKKE FEMSNLQSKI EDEQALAMQL
QKKIKELQAR IEELEEEIEA ERASRAKAEK QRSDLSRELE EISERLEEAG GATSAQIEMN
KKREAEFQKM RRDLEEATLQ HEATAATLRK KHADSVAELG EQIDNLQRVK QKLEKEKSEL
KMEIDDLASN METVSKAKGN LEKTCRTLED QLSEVKMKEE EQQRLINELS AQKARLHTES
GEFSRQLDEK EALVSQLSRG KQAFTQQIEE LKRQLEEESK AKNALAHALQ SARHDCDLLR
EQYEEEQEAK AELQRSMSKA NSEVAQWRTK YETDAIQRTE ELEEAKKKLA QRLQDAEEHV
EAVNSKCASL EKTKQRLQNE VEDLMLDVER SNAACATLDK KQRNFDKVLA EWKQKYEETQ
AELEASQKEA RTLSTELFKV KNAYEESLDH LENLKRENKN LQQEISDLTE QIAEGGKHIH
ELEKVKKQID QEKSELQAAL EEAEGSLEHE EGKILRIQLE LNQVKSEIDR KIPATQRRRP
RRPSLT
//
