ID A0A452SLP5_URSAM Unreviewed; 393 AA.
AC A0A452SLP5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Short chain dehydrogenase/reductase family 42E, member 1 {ECO:0000313|Ensembl:ENSUAMP00000033529.1};
GN Name=SDR42E1 {ECO:0000313|Ensembl:ENSUAMP00000033529.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000033529.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000033529.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR AlphaFoldDB; A0A452SLP5; -.
DR STRING; 9643.ENSUAMP00000033529; -.
DR Ensembl; ENSUAMT00000037346.1; ENSUAMP00000033529.1; ENSUAMG00000025549.1.
DR GeneTree; ENSGT00940000158070; -.
DR OMA; IGAYKRS; -.
DR OrthoDB; 5487986at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd09812; 3b-HSD_like_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 368..391
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 12..284
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 393 AA; 44299 MW; 059A21897BF952B8 CRC64;
MDFQKSPKET VLITGGGGYF GFRLGCALNQ RGFHVILFDI SSPAHAIPEG IKFIHGDIRH
LSDVEKAFQD VDVTCVYHIA SYGMSGREQL NRSLIEEVNV GGTDNILQVC RRRGVPRFVY
TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSIAE KKVLEADGTS LVRRDGVLRT
CALRPAGIYG PGEQRHLPRI VSYIERGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALK
ADKGHIASGQ PYFVSDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLIYCF AFLTETVHFV
LGRFYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYEAQP FDLQEVVEWF KARGHGRSPG
NRDSECLVWD WLVVLLLALA VLTWLPASVV LSL
//
