ID A0A452SME7_URSAM Unreviewed; 3264 AA.
AC A0A452SME7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dachsous cadherin-related 1 {ECO:0000313|Ensembl:ENSUAMP00000033804.1};
GN Name=DCHS1 {ECO:0000313|Ensembl:ENSUAMP00000033804.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000033804.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000033804.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSUAMT00000037651.1; ENSUAMP00000033804.1; ENSUAMG00000025648.1.
DR GeneTree; ENSGT00940000161822; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 26.
DR Gene3D; 2.60.40.60; Cadherins; 27.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF423; PROTOCADHERIN-16; 1.
DR Pfam; PF00028; Cadherin; 22.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 26.
DR SUPFAM; SSF49313; Cadherin-like; 26.
DR PROSITE; PS00232; CADHERIN_1; 11.
DR PROSITE; PS50268; CADHERIN_2; 27.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..3264
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019081742"
FT TRANSMEM 2901..2927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..142
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 143..254
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 255..361
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 374..461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 471..567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 613..651
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 652..756
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 757..860
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 861..966
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 967..1077
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1072..1177
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1190..1290
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1299..1402
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1403..1512
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1512..1615
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1616..1717
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1718..1821
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1822..1926
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1949..2034
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2035..2137
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2138..2243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2243..2342
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2343..2448
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2449..2568
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2569..2672
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2673..2779
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2780..2899
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1083..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2843..2862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2952..3006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3027..3053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3199..3264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3205..3228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3264 AA; 342889 MW; BACCA65CF66D4D56 CRC64;
MQKEAGTAPS CTGMQSSRPL PLVPLLLLLL LLGAGVSGAW GQAGSLDLQI DEEQPAGTLI
GDISAGLPPG TAAPPMYFIS AQEGSGVGTD LAIDEHSGVV RTARVLDRER RDRYRFTAVT
PDGATVEVTV RVADINDHAP AFPQARAALQ IPEHTALGTR YPLEPARDAD AGRLGTQGYA
LSGDGAGQTF QLETRPGPDG APVPELVVTG ELDRENRSQY MLQLEAYDGG SPPRRAQALL
DVTLLDINDH APAFNQSRYH AVVSESLAPG SPVLQVYASD ADAGANGAVT YEINRRQSEG
DGPFSIDAHT GLLRLERPLD FEQRRVHELV VQARDGGAHP ELGSAFVTVN VRDANDNQPS
MTVIFLSADG SPRVSEAAPP GQLVARISVS DPDDGDFAHV NVSLEGGEGH FALSTQDSVI
YLERDAYNLR VTATDSGSPP LRAEATFVLH VTDVNDNAPT FDRQLYRPEP LPEVALPGSF
VVRVMARDPD QGSNGQVTYS LAPGAHTRWF SIDPTSGIIT TAAVLDYELE PQPQLIVVAT
DGGLPPLASS ATVSVALQDV NDNEPQFQRT FYNASLPEGT QPGTCFLQVG KSCTQWDAAV
GRSELKGHRG PQNRNQALQV YLFTVTMSEG LKSMVYVKVF VSDENDNPPQ FYPREYAASL
SAQSTPGTAI LRVRAHDPDQ GPHGRLSYHI LAGNNPPLFA LDEHSGLLTV AWPLARRANS
VVQLEIGAQD GGGLQAEPSA RVNVSIVPGT PVPPVFEQLQ YVFSVPEDVA PGTSVGIVQA
HNPPGRLGSV TLALSGGDPR GLFSLDGASG LLQTLRPLDR ELLGPVLELE VRAGSGVPPA
FAVARVRVLL DDVNDNSPAF PAPEDTVLLP PNTAPGTPIY TLRALDPDAG INSRVTFTLL
AGGGGAFTVD PTTGHVRLMG PLGPPGGPAH ELELEARDGG SPPRTSHFRL RVVVQDLGTR
GLAPHFDSPT YRVDLPSGTS PGTQVLQVQA QAPDGGPITY HLAADGPSNP FGLEPQSGWL
WVRAALDREA QELYTLKVMA VSGSKAELGQ QTGTATVRVS ILNQNDHSPR LSEEPTFLAV
AENQPPGTSV GRVFATDRDS GPNGRLTYSL RPLSEDSKAF RIHPQTGEMT TLQTLDRERQ
SSYQLLVQVQ DGGSPPRSTT GTVHIAVLDL NDNSPSFLQA SGAAGGGLPI QVPDRVPPGT
LVTTLQAKDP DEGENGTILY TLTGPGSELF SLHPHSGELL TAAPLIRAER PHYVLTLSAH
DQGSPPRSSS LQLLVQVLPS VRSAEPPPDP SEPDPAAPVP VVLTVTAAEG LQPGSLLGSV
ASPEPAGVGA LTYTLVGGAD PEGTFALDAS TGRLYLARPL DFEAGPAWRA LTVRAEGPGG
AGARLLRVQV RVQDENEHAP AFARDPLALA LPENPDPGAA LYTFRASDAD GPGPNSDVRY
RLLRQEPPVP ALRLDARTGA LSAPRGLDRE TTPALLLLVE ATDRPANASR RRAARVSARV
FVTDENDNAP VFASPSRVRI PEDQPPGPVA LHVVARDPDL GEAARVSYRL AAGGDGYFRL
HSSTGALSVV RSLDREQRAE HILTVVASDH GSPPRSATQL LTVSVADVND EAPAFQQQEY
SVLLRENSPP GTSLLTLRAT DPDLGANGQV TYGGISGESF SLDPDTGVLT TLRALDREEQ
EEINLTVYAR DRGSPPLLTH VTVRVAVEDE NDHAPTFGSA HLSLEVPEGQ DPQTLTVLRA
SDPDVGANGQ LQYRILDGDP SGAFVLDLAS GEFGSTRPLD REVEPAFQLR IEARDGGQPA
LSATLLVTVT VLDANDHAPA FPVPAYSVEV PEDAPAGTLL LQLQAHDPDA GANGRVTYYL
GTGAAGAFLL EPSSGELRTA TALDREQCPS YAFSVSAVDG AAAGPLSTTV PVTITVRDVN
DHAPTFPTSP LRLRLPRPGP SLSTPTLALA TLRAEDRDAG ANASILYRLA GTPPPGTTVD
SYTGEIRVTR SPVALGPRDR VLFVVATDLG RPARSATGVV IVGLQGESER GPRFPRTSSE
AMLRENAPPG TPVVSPKAVH AGGSSGPITY SILSGNEKGT FAIQPSTGAI TVRSAEGLDF
EASPRLRLVL QAESGGAFAF SVLTLTLQDA NDNAPRFLQP HYVAFLPESR PLEGPLLQVE
ADDLDQGPSG QISYSLAASQ PARGLFHVDP ATGTITTTAI LDREIWAETR LVLMATDRGS
PALVGSATLT VMVIDTNDNR PTIPQPWELQ VSEDALLGSE IAQVTGNDVD SGPVLWYVLS
PSGPQDPFSI GRYGGRLSLT GPLDFEQRDR YHLQLLAHDG PHEGRANLTV FVEDVNDNTP
AFSQSLYQVT LLEHTPPGSA ILSVSATDRD SGANGHISYH LASPAEGFSV DPNNGTLFTT
VGTVAFGQEG PGVVDVVLEA RDHGMPGRAA RATVHVQLQD QNDHTPSFTL PHYRVAVTED
LPPGSTLLTL EATDADGSRT HATVDYSIVS GNRGRVFQLE PRLAETEESS GLGPRALGCL
VLLEPLDFES LTQYNLTVAA ADRGQPPRSS AVPVTVTVLD VNDNPPVFSR ASYRMAVPED
TPVGAELLHV EASDADPGPH GLVRFTLSSG DPSGLFELDE SSGALRLARP LDCETQARHQ
LVVQAADPAG AHFALAPVTI EVQDVNDHGP IFPLSLLSTS LAENQPPGTL VTTLHAIDGD
AGAFGRLRYS LLEAGPGSEG REAFALNSST GELRARVAFD YEHTGSFQLL VGAADAGNLS
ASVTVSVLVT GEDEYDPVFL APAFHFQVPE GARRGYSLGH VQATDEDGGA DGLVLYSLAA
SSPYFGINQT TGALYLRVDS RAPGSGTGNS GSGGRTRREA PRELRLEVVA RGPLPGSRSA
TVPVTVDITH TALGLAPDLN LLLVGAVAAS LGVVVVLALA ALVLGLVRAR SRKAEAAPGP
MSQAAPLASG SLQKLGREPP SPPPSEHLYH QTLPSYGGPG AGGPYPRGGS LDPSHSSGRG
SAEAAEDDEI RMINEFPRVA SVASSLAARG PDSGIQQDAD GLSDTSCEPP APDTWYKGRK
AGLLLPGAGA TLYREEGPPA TATAFLGGCG LSPAPTGDYG FPADGKPCVA GALTAIVAGE
EELRGSYNWD YLLSWCPQFQ PLASVFTEIA RLKDEARPCP PAPRIDPPPL ITAVAHPGAK
SVPPKPASTA ATRAIFPPAS HRSPISHEGS LSSAAMSPSF SPSLSPLAAR SPVVSPFGVA
QGPSASALSA ESGLEPPDDT ELHI
//
