ID   A0A452SN20_URSAM        Unreviewed;      1006 AA.
AC   A0A452SN20;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=CYRIA/CYRIB Rac1 binding domain-containing protein {ECO:0000259|Pfam:PF07159};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000034088.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000034088.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790}.
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DR   AlphaFoldDB; A0A452SN20; -.
DR   Ensembl; ENSUAMT00000037968.1; ENSUAMP00000034088.1; ENSUAMG00000023790.1.
DR   GeneTree; ENSGT00500000044831; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF3; CYTOPLASMIC FMR1-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 2.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          64..273
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
SQ   SEQUENCE   1006 AA;  116974 MW;  BA4D3A48039A8991 CRC64;
     MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN AFVTGIARYI
     EQATVHSSMN EMLEEGHEYA VMLYTWRSCS RAIPQVKCNE QPNRVEIYEK TVEVLEPEVT
     KLMKFMYFQR KAIERFCSEV KRLCHAERRK DFVSEAYLLT LGKFINMFAV LDELKNMKCS
     VKNDHSAYKR AAQFLRKMAD PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD
     IVNICVDYYE NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK
     QLQVVPLFGD MQIELARYIK TSAHYEENKS NLSEPQFIYQ WGIMIVVTGS GLDSQKSDEE
     YRELFDLALR GLQLLSKWSA HVMEVYSWKL VHPTDKFCNK DCPGTAEEYE RATRYNYTSE
     EKFAFVEVIA MIKGLQVLMG RMESVFNQAI RNTIYAALQD FAQVTLREPL RQAVRKKKNV
     LISVLQAIRK TICDWEGGRE PPNDPCLRGE KDPKGGFDIK VPRRAVGPSS TQLYMVRTML
     ESLIADKSGS KKTLRSSLDG PIVLAIEDFH KQSFFFTHLL NISEALQQCC DLSQLWFREF
     FLELTMGRRI QFPIEMSMPW ILTDHILETK EPSMMEYVLY PLDLYNDSAY YALTKFKKQF
     LYDEIEAEVN LCFDQFVYKL ADQIFAYYKA MAGSVLLDKR FRAECKNYGV IIPYPPSNRY
     ETLLKQRHVQ LLGRSIDLNR LITQRISAAM YKSLDQAISR FESEDLTSIV ELEWLLEINR
     LTHRLLCKHM TLDSFDAMFR EANHNVSAPY GRITLHVFWE LNFDFLPNYC YNGSTNRFVR
     TAIPFTQEPQ RDKPANVQPY YLYGSKVSSL GCVLLLRRLV SKSKQKSVPQ IRKVERCRDR
     EAAVRSRQIL LIIVKIVYGL NKMEMGYEVV CDCLKAGKHY RARLLNLSKM IPPTAEGTGR
     LPQLTESITQ RAHLQLKSFL EVLCFIKSCK FCFLCHNLFM IVLTLK
//