ID A0A452SNN6_URSAM Unreviewed; 280 AA.
AC A0A452SNN6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=TNF receptor superfamily member 14 {ECO:0000313|Ensembl:ENSUAMP00000034358.1};
GN Name=TNFRSF14 {ECO:0000313|Ensembl:ENSUAMP00000034358.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000034358.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000034358.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A452SNN6; -.
DR STRING; 9643.ENSUAMP00000034358; -.
DR Ensembl; ENSUAMT00000038264.1; ENSUAMP00000034358.1; ENSUAMG00000026142.1.
DR GeneTree; ENSGT00940000162427; -.
DR OMA; GWELPPW; -.
DR OrthoDB; 24515at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:1905675; P:negative regulation of adaptive immune memory response; IEA:Ensembl.
DR GO; GO:0031295; P:T cell costimulation; IEA:Ensembl.
DR CDD; cd00185; TNFRSF; 1.
DR CDD; cd10582; TNFRSF14; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022332; TNFR_14.
DR InterPro; IPR034031; TNFRSF14/UL144_N.
DR PANTHER; PTHR46838; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR PANTHER; PTHR46838:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR PRINTS; PR01965; TNFACTORR14.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019585388"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..119
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 77..119
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 120..162
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 120..162
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DISULFID 78..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 144..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 280 AA; 30136 MW; 754829CAB8F1F099 CRC64;
MEPLRGWELP PWSLTPKADA LHQALYLLLL GSLPCALAMA PCKEEEYPVG SECCPKCSPG
YRVKEACGEL TGTLCVPCDP GTYTAHLNGL SECLQCRVCD PALGLVTRQK CSRTENTVCV
CDQGHFCISE DGDDCAECRP HTLCRPGQRV RARGTERQDR VCEDCPSGTF SPSGTLEECQ
PWTTCSGPFQ TEAEPGTSIS DITCSSRGLY VFVGSLVLIG VLCGLIVLGI RMKNRRSPGG
PTKARLFHQV PRAPPDITTV ALEETASVSP VSLPCVTGRE
//
