ID A0A452SNV8_URSAM Unreviewed; 1633 AA.
AC A0A452SNV8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Cytoskeleton associated protein 5 {ECO:0000313|Ensembl:ENSUAMP00000034372.1};
GN Name=CKAP5 {ECO:0000313|Ensembl:ENSUAMP00000034372.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000034372.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000034372.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR Ensembl; ENSUAMT00000038278.1; ENSUAMP00000034372.1; ENSUAMG00000025271.1.
DR GeneTree; ENSGT00390000014757; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 2.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..192
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 129..167
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 214..446
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 478..710
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 821..1059
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 179..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1598..1618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1633 AA; 181747 MW; 3CE89E2B2E044946 CRC64;
MLCIRDCLIE GIWKEVVGKD TNVMLVALAA KCLTGLAVGL RKKFGQYAGH VVPTILEKFK
EKKPQVVQAL QEAIDAIFLT TTLQNISEDV LAVMDNKNPT IKQQTSLFIA RSFRHCTAST
LPKSLLKPFC AALLKHINDS APEVRDAAFE ALGTALKVVG EKAVNPFLAD VDKLKLDKAG
GPPKKGKTAA PGGAGSAGTK NKKGLETKEI VEPELSIEVC EEKASAVLPA TCIQLLDSSN
WKERLACMEE FQKAVELMDR TEMPCQALVR MLAKKPGWKE TNFQVMQMKL HIVALIAQKG
NFSKTSAQIV LDGLVDKIGD VKCGNNAKEA MTAIAEACML PWTAEQVMSM AFSQKNPKNQ
SETLNWLSNA IKEFGFSGLN VKAFISNVKT ALAATNPAVR TSAITLLGVM YLYVGPSLRM
FFEDEKPALL SQIDAEFEKM QGQSPPAPTR GISKHSISGT DEGEDGDEPD EVGTDVVDLL
PRTEISDKIT SELVSKIGDK NWKIRKEGLD EVAAIINEAK FIQPNIGELP TALKGRLNDS
NKILVQQTLN ILQQLAVAMG PNIKQHVKNL GIPIITVLGD SKNNVRAAAL ATVNAWAEQT
GMKEWLEGED LSEELKKENP FLRQELLGWL AEKLPTLRST PTDLILCVPH LYSCLEDRNG
DVRKKAQDAL PFFMMHLGYE KMAKATGKLK PTSKDQVLAM LEKAKANMPA KPAASAKATS
KPVGGSAPAK FQPASGNSIL RGLREKEVAQ GNSKKKSSLH FLPYFQTSAQ GKKVPSKTSL
KEDEDKSGPI FIVVPNGKEQ RMKDEKGLKV LKWNFTTPRD EYIEQLKTQM SSCVAKWLQD
EMFHSDFQHH NKALAVMVDH LESEKEGVIG CLDLILKWLT LRFFDTNTSV LMKALEYLKL
LFTLLSEEEY HLTENEASSF IPYLILKVGE PKDVIRKDVR AILNRMCLVY PASKMFPFIM
EGTKSKNSKQ RAECLEELGC LVESYGMNVC QPTPGKALKE IAIHIGDRDN AVRNAALNTI
VTVYNVHGDQ VFKLIGTLSE KDMSMLEERI KRSAKRPSAA PVKQVEEKPP RTQSVNSNAS
MQRKGPAEDM SSKLNQARSM SGHPEAAQMV RREFQLDLDE IENDNGTVRC EMPELVQHKL
DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA SGDINTSIQA LTQIDEVLRQ
EDKAEAMSGH IDQFLIATFM QLRLIYNTHM ADEKLEKDEI IKLYSCIIGN MISLFQIESL
AREASTGVLK DLMHGLITLM LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD QTNILSLGQV
NGDRNSLHSS CLWRMVRLLP DTINSINLDR ILLDIHIFMK VFPKEKLKQC KSEFPIRTLK
TLLHTLCKLK GPKILDHLTM IDNKNESELE AHLCRMMKHS MDQTGSKSEK ETEKGASRID
EKSSKAKVND FLAEIFKKIG SKENTKEGLA ELYEYKKKYS DADIEPFLKN SSQFFQSYVE
RGLRVIEMER EGKGRIPTST GMASSSEEVG PSVYLERLKI LRQRCGLDNT KVQDERPPLT
SLLSKPAVPP VASSTDMLHS KLSQLRESRE QHQHSDLDSN QTHSSGTMTT SSSSTANIDD
LKKRLERIKS SRK
//