ID A0A452SR77_URSAM Unreviewed; 98 AA.
AC A0A452SR77;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cystatin B {ECO:0000313|Ensembl:ENSUAMP00000035251.1};
GN Name=CSTB {ECO:0000313|Ensembl:ENSUAMP00000035251.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000035251.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000035251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cystatin family.
CC {ECO:0000256|ARBA:ARBA00009403}.
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DR AlphaFoldDB; A0A452SR77; -.
DR STRING; 9643.ENSUAMP00000035251; -.
DR Ensembl; ENSUAMT00000039239.1; ENSUAMP00000035251.1; ENSUAMG00000026763.1.
DR GeneTree; ENSGT00940000154826; -.
DR OMA; MKPHAEK; -.
DR OrthoDB; 179019at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
DR GO; GO:0045861; P:negative regulation of proteolysis; IEA:Ensembl.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR InterPro; IPR001713; Prot_inh_stefin.
DR PANTHER; PTHR11414; CYSTATIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11414:SF22; CYSTATIN-B; 1.
DR Pfam; PF00031; Cystatin; 1.
DR PRINTS; PR00295; STEFINA.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..98
FT /note="Cystatin"
FT /evidence="ECO:0000259|SMART:SM00043"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 98 AA; 11207 MW; E2AD4EE4F3BB0C4E CRC64;
MMCGAPTASQ PATAETQSIA DQVKPQLEER ENKKYATFKA VEFRSQVVAG RNYFIKVQVD
DDEFVHLRVF QSLPHENKPL ALSSYQTNKA RHDELAYF
//
