ID A0A452SS86_URSAM Unreviewed; 1292 AA.
AC A0A452SS86;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Multidrug resistance-associated protein 1-like {ECO:0008006|Google:ProtNLM};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000035582.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000035582.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 9643.ENSUAMP00000035582; -.
DR Ensembl; ENSUAMT00000039618.1; ENSUAMP00000035582.1; ENSUAMG00000027023.1.
DR GeneTree; ENSGT00940000162802; -.
DR OMA; RGTMEFF; -.
DR OrthoDB; 3384185at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18595; ABC_6TM_MRP1_2_3_6_D1_like; 1.
DR CDD; cd18603; ABC_6TM_MRP1_2_3_6_D2_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF166; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1-LIKE ISOFORM X1; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 158..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..403
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 435..659
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 728..1002
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1048..1282
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 145985 MW; E4B4BAB3F62287BF CRC64;
MFFSPRRWGA SSDYERVPEG PGAQKCNPEK SASFFSRMTY SWFSRIIVLG YKKPLEREDL
FELNESDSSY VVCPIFEKQW RKEVLRNQER QKVKASFHKE AHARKPSLVY ALWNTFKFVL
IQVALFKVFA DILSFTSPLI MKQMIIFFEH RPDFGWSGYG YALALFVVVF LQTLILQQYQ
RFNMLTSAKI KTAVIGLIYK KALLLSNVSR KRFSAGEVIN LMSADAQQLM DLTANLNLLW
SAPFQILMAV SLLWQELGPA VLAGVAVLVF VIPINALVAT RVKKLKKSQT KNKDKQIKLL
NEILHGIKIL KLYAWEPSYK KKIIEIREQE LEVQKLSGYL AVFSMLTLTC IPFLVSLATF
GIYFLLDEGN ILTATKVFTS MSLFNILRLP LFDLPMVISA VVQTRISLDR LEDFLNTEEL
HPQNIETNYV GDHAIGFTNA SFSWDKTGIP VLENLNIKIP EGALVAVVGQ VGSGKSSVLS
AILGEMEKLT GVVQRKGSVA YVAQQAWIQN CILQENVLFG SIMQKQFYER VLEACALLPD
LEQLPNGDQT EIGERGVNIS GGQKHRVSLA RAVYSGADIY LLDDPFAAVD VHIGKQLFEK
VIGPSGILKN KTRILVTHNL TLLPQMDLIV VMESGRVAHM GTYQELLSKT RNLTNLLQAF
SEQEKAHALK RVSVINSRLK DQILEQNDRP SLDQGKQFSM KKEKIPIGGV KFSVILKYLQ
AFGWLWVWLS LAAYLGQNLV GIGQNLWLSA WVKEAKHMSE FTEWEQIRSN KLNIYGLLGL
MQGLFVCSGA YILTRGSLAA SRTLHTQLLD NVLHLPLRFF ETNPIGQIIS RFTKDMFIID
IRFHYYLRTW VNCTLDVIGT VLVIAGALPL FILGVIPLVF LYFTIQRYYV ASSRQIRRLA
GASRSPIISH FSETLSGVST IRAFGHEQRF IQQNREVVNE NLVCFYNNVI SNRWLSVRLE
FLGNLMVFFA ALLAVLAANS IESAIVGLSI SYALNITQSL NFWVRKACEI ETNAVSIERV
CEYENMDKEA PWIMSKRPPS QWPDKGIVEF INYQARYRDD LGLALQDITF QTHGEEKIGI
VGRTGAGKST LSNCLFRIVE RSGGKIIIDG IDISTIGLHD LRGKLNIIPQ DPVLFSGTLQ
MNLDPLDKYS DSELWEVLEL CHLKEFVQSL PKKLLHEISE GGENLSVGQR QLVCLARALL
RKTKILILDE ATASIDFETD NLVQTTIRKE FSDCTILTIA HRLHSIIDSD RVLVLDSGRI
TEFETPQNLI CQKGLFFQML TEAGITQDSV TK
//
